摘要：目的 阐述植物化学物对肺癌的预防作用，展望其应用前景。方法 以十字花科蔬菜及其生物活性成分异硫氰酸酯为例，从流行病学研究、动物实验、临床研究及作用机制方面，综述植物化学物对肺癌化学预防作用的研究进展。结果 研究发现，十字花科蔬菜可降低人群患肺癌的风险，这种保护作用独立于吸烟因素。异硫氰酸酯可抑制多种致癌物诱导的动物肺肿瘤的发生。人体食用富含异硫氰酸酯的西兰花可增强呼吸系统的免疫力和对环境致癌物的解毒能力。异硫氰酸酯通过抑制致癌物在体内的活化，诱导细胞保护酶，抑制炎症反应，调节免疫，阻滞细胞周期和促进细胞凋亡，干扰信号通路等多种途径发挥肿瘤预防的作用。结论 富含植物化学物的食物及其提取物对肺癌的预防具有很好的应用前景。

Abstract：Objective To elaborate chemoprevention of phytochemicals for lung cancer and look forward to its application prospect. Methods Taking Cruciferous vegetables and its bioactive components isothiocyanates as an example, research advances of chemoprevention of phytochemicals for lung cancer would be reviewed in terms of epidemiological studies, animalexperiments, clinical research and its action mechanism. Results Cruciferous vegetables could reduce the risk of lung cancer, which was independent of smoking. Phytochemicals rich in cruciferous vegetables named as isothiocyanates could inhibit animal model suffering from lung cancer induced by a variety of carcinogens. A diet rich in broccoli could enhance the immunity of respiratory system and improve the detoxification ability toenvironment carcinogens. The multiple mechanisms of cancer chemoprotective effect involved inhibition of the carcinogen activation, induction of protective enzymes, suppression of inflammation reaction, regulation of immunity, interruption of cell cycle, promotion of apoptosis and perturbation of signaling pathways. Conclusions Food and its extract rich in plant chemicals could serve as prospective alternatives for prevention of lung cancer.