摘要：目的 总结泛素蛋白酶体系统在肿瘤恶液质中的研究进展，归纳该系统的调节通路以及在恶液质治疗中的可能靶点。方法 以“肿瘤、恶液质、泛素、蛋白酶体”作为关键词检索Pubmed数据库获得相关文献。结果 荷瘤条件下失调的细胞因子可以通过泛素蛋白酶体系统促进骨骼肌蛋白降解，参与了恶液质的发生发展。结论 泛素蛋白酶体系统通路可能成为恶液质治疗的新靶点，阐明蛋白酶体特异性识别机制和上游调控因子有助于恶液质临床治疗的进展。

Abstract:Objective To summarize the late advance of ubiquitin-proteasome system in cancer cachexia and conclude its regulatory mechanisms and possible targets of cachexia therapy. Methods Related articles were obtained through comprehensive search in the database Pubmed with the keywords“cancer, cachexia, ubiquitin, proteasome”. Results Dysregulated cytokines resulting from cancer bearing promote muscle protein degradation via ubiquitin-proteasome system, which benefits for initiation and progression of cancer cachexia. Conclusions The ubiquitin-proteasome system may be a novel target of cachexia therapy. Elucidation of how ubiquitinated proteins are specifically recognized by proteasome and identification of its upstream regulatory factors would contribute to improvement of clinical therapy in cachexia.