摘要：目的 本研究探讨牛血清白蛋白纳米微粒的制备及其在荷人乳腺癌SK-BR3细胞的裸鼠体内的分布和代谢。方法 125 采用超声乳化-化学交联制备白蛋白纳米颗粒，通过I进行标记探讨其在荷人乳腺癌SK-BR3细胞裸鼠体内的分布和代谢。结果 制备的牛血清白蛋白纳米颗粒平均粒径为34nm，90%的粒径小于38nm。牛血清白蛋白纳米颗粒与牛血清白蛋白在肿瘤、肝、胃、肠等器官的分布有显著的靶向性，差异有统计学意义(P<0.05)。在脑的分布均较少，没有发现明显的靶向作用。结论 牛血清白蛋白纳米颗粒具有对肿瘤、肝、胃肠等器官的良好器官靶向性，同时具备成为中枢神经系统给药的比较理想的载体的条件。

Abstract: Objective This study was designed to explore the preparation of bovine serum albumin nanoparticles and its application and metabolism in nude mice bearing human breast cancer cell line SK-BR3 in vivo. Methods The distribution and metabolism of albumin nanoparticles with the mark of 125I prepared by the method of phacoemulsification-chemical cross-linking were discussed in nude mice bearing human breast cancer cell line SK-BR3 in vivo. Results The average size of bovine serum albumin nanoparticles prepared is 34 nm, 90% of which is less than 38 nm. Bovine serum albumin nanoparticles and bovine serum albumin had obvious targeting at tumor, liver, stomach, intestinal and other organs, and the difference was significant (P<0.05), but less in brain with no obvious targeting. Conclusions Bovine serum albumin nanoparticles with such good targeting at tumor, liver,gastrointestinal organs may be an ideal carrier of drug deliver in central nervous system, which can be produced to be a higher targeting nanoparticles with further surface modification.