摘要：目的 探讨脂肪动员因子LMF/ZAG在肿瘤恶液质中的作用。方法 对相关文献进行综述分析。结果 LMF/ZAG是肿瘤恶液质中促进脂肪动员、分解的关键因子，它通过GTP依赖性环腺苷酸通路直接刺激脂肪细胞内脂肪酸水解，增强脂肪动员，加速机体贮存脂—白色脂肪组织消耗和氧化利用，对肿瘤患者的能量和脂肪代谢平衡发挥着至关重要的作用。同时其诱导的脂代谢改变及其代谢产物，对机体整体蛋白和糖类的代谢也有重要影响。结论 LMF/ZAG是肿瘤恶液质中脂肪消耗的关键因子，对恶液质状态物质代谢紊乱有重要的作用。

Abstract: Objective To summarize the function of lipid-mobilizing factor/Zn-α2-glycoprotein in cancer cachexia. Methods The related literatures were reviewed. Results LMF/ZAG can stimulate fat mobilization and triglyceride hydrolysis in adipose tissue directly via GTP dependent cAMP pathway, and accelerate the consumption and oxidation of white adipose tissue, thus playing a vital role in lipid metabolism and energy balance in cancer cachexia. Meanwhile the changes of lipid metabolism induced by LMF/ZAG and their metabolic products have an important influence on the whole body protein and glucose metabolism. Conclusions LMF/ZAG acts as the key factor of fat consumption and plays an important role in the whole material metabolic disorders in cancer cachexia.