摘要：目的 肿瘤细胞的葡萄糖代谢呈现出有别于正常细胞的显著特征，即有氧酵解或Warburg效应，本文介绍Akt家族成员、蛋白质结构、生理功能，重点讨论Akt在肿瘤细胞的糖代谢作用及其机制。方法 以Akt、cancer及glucose从pubmed上检索相关文献，并对研究结果进行提炼。结果 Akt是胰岛素-生长激素受体网络信号中一个关键下游效应分子，在人类肿瘤中常常发生显著的变化，深度介入细胞的生存、生长、代谢及癌变。结论 Akt是人类肿瘤中最常见的一个与肿瘤代谢相关的癌基因，对肿瘤细胞生长及糖代谢的调控发挥关键作用。

Abstract: Objective Warburg observed that rapid growing tumor cells manifest an increase in glucose uptake, an enhancement of glycolytic capacity and a high lactate production, along with the absence of respiration despite the presence of high oxygen concentration, a phenomenon known as the ''Warburg effect''. This paper outlined Akt's family members, protein structure and cellular functions, but mainly focused on its physiological functions in the regulation of glucose uptake and metabolism in mitochondria, addressed the metabolic phenotypes of tumor and proliferating normal cells and the role of Akt in the glucose metabolism of cancer cells. Methods Using Akt, cancer and glucose as key words, we searched, reviewed the literatures in pubmed and recruited related data. Results Akt, a key effector downstream of insulin and growth factor receptor signaling networks and one of the most common alterations detected in spontaneous human tumors, profoundly involved in the regulation of cell survival, cell growth, cell metabolism and oncogenesis.Conclusions Akt plays an important role in cancer cell metabolic adaptations and oncogene-directed metabolic reprogramming required for supporting an anabolic tumor growth. Altered Akt activation may lead to enhanced glucose uptake and glycolysis in tumor cells. Growth factor receptor signaling pathways, such as Akt signaling pathway, and certain transcription factor networks participate in a major reorganization of metabolic activities into a platform that support the bioenergetics and biosynthetic demands of a proliferating tumor cell to duplicate itself, and to survive fluctuations in external nutrient and oxygen availability during tumor growth.