目的 阐述牛磺酸的生理学作用，探讨其作为一种人体营养添加剂对不同疾病的作用。 方法 回顾近年来国内外 发表的涉及牛磺酸对人体各系统的影响及机制、牛磺酸缺乏所致人体病理状态，以及有关牛磺酸补充治疗的中、英文文献。 结果 牛磺酸是人体内的一种重要生理活性物质，参与体内一系列生理学过程，如胆汁酸结合、渗透压调节、改善体内氧化 应激状态、细胞膜的稳定、细胞钙流动调节、神经营养和保护、调节糖代谢等，牛磺酸缺乏可导致人体发生多种病变及加 重原有病理状态。目前牛磺酸作为一种营养添加剂已广泛用于婴儿配方奶粉、肠内营养制剂。 结论 牛磺酸作为人体的一种 重要营养添加剂，适量补充有益于改善患者体内氧化应激状态，调节代谢平衡，减轻病变或延缓病程进展，从而有利于临 床结局。

Objective To discuss taurine act as a kind of human nutritional supplements on the role of different diseases by elaborating physiological effects of taurine. Methods We review the domestic and foreign published literature in recent years on the role of taurine, pathological state caused by taurine defciency, and taurine supplementation in human body. Results Taurine is an important biological active substance in human body. It involves in many physiological activities, including binding bile acid, regulating the osmotic pressure, improving in vivo oxidative stress, stabling cell membranes, regulating cellular calcium ion ?ow, acting as neurotrophic and neuroprotective properties and regulation glucose metabolism. Taurine defciency will result in a variety of pathological conditions in human body and lead to exacerbation of original increases. Taurine has been widely used in powdered formulas of infant and enteral nutrition preparation. Conclusions Acting as an important human nutritional supplement, appropriate taurine supplementation may help patients improve the state of oxidative stress, regulate metabolic balance, reduce or delay the progression of lesions. Thus it can facilitate the clinical outcome of patients.