肿瘤发生、发展的过程中需要有新生物质的不断合成与能量的持续供应，以适应肿瘤细胞生长与转移的需求。 目前研究大多数集中于探讨原发肿瘤浸润生长的代谢方式，对于原发病灶生长过程中代谢变化规律的报道并不多见。研究表明，有氧糖酵解是肿瘤细胞能量代谢的主要特征，糖酵解增强可能是肿瘤浸润生长重要的代谢特征之一。同一种肿瘤中，糖酵解和氧化磷酸化可以同时存在，相互协调，产生代谢共生的作用。另外，间质的代谢方式对肿瘤的浸润生长同样具有重要的作用。除此之外，越来越多的证据表明肿瘤细胞一旦离开原发病灶进入血液循环，就会发生许多不同于原发病灶的代谢改变，以利于自身转移后的生存。另有相关证据表明，肿瘤细胞的代谢方式决定了转移后的器官选择性，器官的代谢方式同时可能也促进了肿瘤细胞的定植转移。因此，肿瘤发生、发展的过程也是一个代谢不断变化的过程。本文就肿瘤细胞在原发病灶浸润生长过程中以及发生转移后可能发生的系列代谢性变化进行综述。

As we know, tumor is a metabolic disease. During tumor development, cancer cells need to increase the biosynthetic and bioenergetic demands to maintain tumor cell proliferation and metastasis. The focus has been mostly on the metastatic style of the primary tumor, while metabolic adjustments during primary tumor growth and metastatic process have been less well known. Present evidences indicate that metabolic regularity of tumor development is dynamic. Moreover, emerging data suggest that, once the tumor cells leave their primary sites, may show different metabolic styles, distinct from the primary tumor, to successfully survive and metastasis. In this review, we will summarize how the metabolic flexibility will be occurred during the primary tumor growth and metastatic process, and we will also explore how metabolic adaptation is influenced by the metastatic microenvironments. We hope that this review will give information for the tumor metabolic research in the future.