目的 探讨营养干预对晚期子宫内膜癌恶液质患者代谢改变。方法 随机选取本院2015年6月至2017年6月收治的晚期子宫内膜癌恶液质患者70例，按随机数字法将其随机分为对照组和试验组，对照组采用常规自主进食干预，试验组采用营养干预，检测干预前后各营养指标和各代谢相关指标，并统计分析其差异性。结果  经比较对照组干预前后BMI、红细胞、血清白蛋白、血红蛋白各营养指标值之间的差异不具有统计学意义（P＞0.05）；试验组干预前后各营养指标值之间的差异均具有统计学意义（P＜0.05）。干预前试验组各营养指标值与干预前对照组各指标值之间的差异均不具有显著性（P＞0.05），但是干预后试验组各营养指标值均显著高于干预后对照组各指标值，其差异均具有统计学意义（P＜0.05）。经比较对照组干预前后腰围、高密度脂蛋白、甘油三酯、收缩压、舒张压、血糖各指标值之间的差异无统计学意义（P＞0.05）；试验组干预后腰围、高密度脂蛋白、甘油三酯、血糖各指标值均显著高于试验组干预前各指标值，其差异均具有统计学意义（P＜0.05），但收缩压和舒张压在两组之间的差异无统计学意义（P＞0.05）；干预前试验组腰围、高密度脂蛋白、甘油三酯、收缩压、舒张压、血糖各指标值与干预前对照组各指标值之间的差异均不具有统计学意义（P＞0.05）。干预后试验组腰围、高密度脂蛋白、甘油三酯、血糖各指标值均要显著高于干预后对照组各指标值，其差异均具有统计学意义（P＜0.05），但是收缩压、舒张压在干预后试验组和对照组之间的差异不具有统计学意义（P＞0.05）。结论 营养干预能显著改善晚期子宫内膜癌恶液质患者的营养状况和代谢相关指标。

Objective To investigate the metabolic changes of cachexia in women with advanced endometrial cancer by nutritional intervention. Methods70 patients with advanced endometrial cancer cachexia were randomly selected in our hospital from June 2015 to June 2017 were randomly divided into control group and experimental group, the control group using conventional self feeding intervention, the experimental group with nutrition intervention, the nutrition indexes and the metabolism related indexes before and after intervention, and statistical analysis the difference. ResultsAfter comparing the difference between the value of the nutritional indexes of BMI, blood cells, serum albumin, hemoglobin group before and after the intervention was not statistically significant (P>0.05); The experimental group before and after the intervention of the nutrition indexes between the values of the differences were statistically significant (P<0.05). Before the intervention experiment group before intervention and nutritional value index differences between each index value of the control group were not statistically significant (P>0.05), but after the intervention group were significantly higher than the nutritional value index after the intervention control group each index value, the differences were statistically significant (P<0.05). Compared with the control group before and after the intervention of waist circumference, high density lipoprotein, triglyce ride, systolic pressure, diastolic pressure, the difference between the blood glucose index was not statistically significant (P>0.05); The experimental group did each prognostic index for waist circumference, high density lipoprotein, triglycerides, blood glucose levels were significantly higher than the experimental group before the intervention of each index value. The differences were statistically significant (P<0.05), but no statistically significant difference in systolic blood pressure and diastolic blood pressure between the two groups (P>0.05); The experimental group before the intervention of waist circumference, high density lipoprotein, triglyceride, systolic blood pressure, diastolic blood pressure, blood sugar index before and after the difference between the index value of the control group were not statistically significant (P>0.05). Do the test group of prognostic index for waist circumference, high density lipoprotein, triglycerides, blood glucose values were significantly higher than the control group after intervention of each index value, the differences were statistically significant (P<0.05), but the systolic blood pressure and diastolic blood pressure in the stem was not statistically significant differences between prognosis of the experimental group and the control group (P>0.05). ConclusionNutritional intervention can significantly improve the nutritional status and metabolic markers in patients with advanced endometrial cancer cachexia.