目的 通过动物模型探讨短肽型肠内营养制剂对肠道病变的营养作用。方法 采用甲氨喋呤注射成年SD雄性大 鼠建立肠黏膜炎模型42只，空白对照组14只。将肠黏膜炎大鼠随机分为3组，即：正常饲料饲养组，蛋白型肠内营养制剂组，短肽型肠内营养制剂饲养组。所有大鼠每日均予以膳食38kcal/100g。每日记录各组大鼠进食量、体重情况，饲养后0天、3天、9天、15天分别于大鼠尾部同一部位取血，检测其血清总蛋白、清蛋白、前蛋白、转铁蛋白、视黄醇结合蛋白及二胺氧化酶。饲养15天后处死大鼠，取肠道组织行病理学检查评估肠道损伤情况。结果 短肽型肠内营养喂养组体重及进食情况较正常饲料组和整合蛋白组佳（P＜0.05）。第15天时检测的血清总蛋白、白蛋白、前白蛋白、转铁蛋白指标提示，短肽型肠内营养制剂组显著高于正常对照饲养组和整蛋白喂养组（P＜0.05），二胺氧化酶指标则低于正常饲养和整合蛋白组（P＜0.05），同时病理HE染色提示，短肽型肠内营养制剂组损伤较其余两组轻。结论 肠道黏膜在损伤条件下口服短肽型营养制剂，不仅有利于大鼠营养状况的改善，而且有助于其肠道黏膜损伤的恢复。  

Objective To explore the nutritional effect of short peptide enteral nutrition on intestinal mucositis rats. Methods42 model of intestinal mucosa was established by methotrexate injection. SD rats were randomly divided into blank control group (n=14) and control group (n=14). Successful models were randomly divided into 3 groups: normal diet group, protein enteral nutrition group, short peptide enteral nutrition preparation group. Rats were given daily diets of 38kcal/100g. The serum levels of total protein, albumin, proprotein, transferrin and retinol were measured in the tail of rats at day 0, 3, 9 and 15 days after feeding. Protein and diamine magnesium oxide, and the rats were sacrificed 15 days after feeding, and pathological examination was performed to evaluate the intestinal injury. ResultsThe model of intestinal mucosal injury was established by methotrexate injection. The body weight and feeding rate of the short-peptide-type were better than those of the normal diet group and the integrated protein group (P<0.05). The rats were sacrificed at day 15, and the serum total protein, albumin, proprotein and transferrin were measured (P<0.05), and the diamine oxidase was decreased (P<0.05) compared with normal feeding and integrated protein group, while HE staining and short peptide. The damage of the internal nutrition group was lighter than that of the other two groups. ConclusionsPeptide preparation for intestinal mucosal injury is not only beneficial to the improvement of nutritional status in rats, but also contributes to the recovery of injury.