目的 了解中国胃肠道恶性肿瘤(GIC)患者的生活质量现状,探讨总体社会经济地位( SES)与生活质量的关联。 方 法 依托常见恶性肿瘤患者营养状况与临床结局相关性研究(INSCOC),选取 2013 年 10 月至 2023 年 10 月的 GIC 患者作为研 究对象。 使用欧洲癌症研究与治疗组织生活质量问卷(EORTC QLQ-C30)进行生活质量评估,采用线性回归模型分析 SES 和 生活质量的关联。 结果 共纳入 12 006 例 GIC 患者,生活质量总体评分平均(86. 77±12. 04) 分。 多重线性回归分析结果显 示,GIC 患者的总体 SES 与生活质量总分( b = 1. 89,P< 0. 001; b = 1. 94,P< 0. 01)、功能领域总分( b = 14. 90,P< 0. 001; b = 17. 75,P<0. 001)、总体健康状况/ 生活质量总分(b = 3. 21,P<0. 001; b = 4. 19,P<0. 001)呈正相关,与症状领域和单一条目总 分(b = -21. 01,P<0. 001; b = -26. 28,P<0. 001)呈负相关。 3 个 SES 指标与生活质量总体评分、功能领域、总体健康状况/ 生活 质量以及症状领域和单一条目总分的关联与总体 SES 相似,但其中就业情况与总体健康状况/ 生活质量的关联并不显著。 结 论 中国 GIC 患者的生活质量还有待改善,应加强 GIC 患者的社会经济支持,提高其生活质量。

Objective To examine the quality of life QoL among patients with gastrointestinal cancer GIC in China and to explore the association between overall socioeconomic status SES and QoL. Method Data were derived from the Investigation on Nutrition Status and Its Clinical Outcome of Common Cancers INSCOC . Patients with GIC from October 2013 to October 2023 were selected. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 EORTC QLQ-C30 was used for QoL assessment. A linear regression model was applied to analyze the relationship between SES and QoL. Result A total of 12 006 GIC patients were included with a mean QoL summary score of 86. 77 ± 12. 04. Multiple linear regression analysis showed that overall SES was positively correlated with the QoL summary score b = 1. 89 P < 0. 001 b = 1. 94 P < 0. 01 functional scale b = 14. 90 P < 0. 001 b = 17. 75 P < 0. 001 and global health status/ QoL b = 3. 21 P < 0. 001 b = 4. 19 P < 0. 001 and negatively correlated with symptom scale / item scores b = -21. 01 P < 0. 001 b = -26. 28 P < 0. 001 . The associations between the three SES indicators and QoL summary score functional scale global health status/ QoL and symptom scale / item were similar to the overall SES. However employment status was not significantly associated with global health status/ QoL. Conclusion The QoL of patients with GIC in China needs improvement. Social and economic support should be strengthened to enhance their quality of life.