胃癌严重影响人类健康,已经成为全球关注的重大健康问题,在其复杂的发病机制中,基因调控网络扮演着重要角 色。 其中,竞争性内源 RNA(ceRNA)调控网络又是一个重要的研究领域。 这个网络涉及多种 RNA 分子之间的相互作用,包 括 mRNA、miRNA、lncRNA 和 circRNA 等,它们通过复杂的调控机制精确控制基因表达,从而影响胃癌的发生、发展。 正反馈 环路是生物体内中不可或缺的信号转导机制,它通过循环增强初始信号来加速或放大特定的生物学过程,不仅在细胞生长、 发育和应对各种生理、病理刺激中起到至关重要的作用,而且可以通过多方面参与肿瘤的发生、发展,如促进肿瘤细胞的增殖 和侵袭、改变肿瘤微环境和增加肿瘤细胞化疗抗性。 在 ceRNA 调控网络中也存在着正反馈环路,这些正反馈环路通过放大特 定信号从而调节细胞增殖、凋亡、迁移和侵袭等关键过程潜在地驱动胃癌发生、发展。 因此,深入研究 ceRNA 调控网络相关正 反馈环路对于揭示胃癌的发病机制、发现新的潜在治疗靶点具有重要意义。 本文综述了 ceRNA 调控网络相关正反馈环路在 胃癌中的作用及其分子机制,并展望其在胃癌治疗中的应用前景。

Gastric cancer severely affects human health and has become a significant health issue of global concern. In its complex pathogenesis genetic regulatory networks play an important role. Among them the competitive endogenous RNA ceRNA regulatory network is an important field of research. This network involves the interaction between various types of RNA molecules including mRNA miRNA lncRNA and circRNA etc. They precisely control gene expression through complex regulatory mechanisms thereby affecting the occurrence and development of gastric cancer. Positive feedback loops are indispensable signaling mechanisms within biological systems they accelerate or amplify specific biological processes by cyclically enhancing initial signals. They play a crucial role not only in cell growth development and response to various physiological and pathological stimuli but also participate in the occurrence and development of tumors in many ways such as promoting the proliferation and invasion of tumor cells changing the tumor microenvironment and increasing the chemoresistance of tumor cells. Positive feedback loops also exist within the ceRNA regulatory network. These loops potentially drive the occurrence and development of gastric cancer by amplifying specific signals to regulate key processes such as cell proliferation apoptosis migration and invasion. Therefore in - depth study of the positive feedback loops related to the ceRNA regulatory network is of great significance for revealing the pathogenesis of gastric cancer and discovering new potential therapeutic targets. This article reviews the role and molecular mechanisms of ceRNA - related positive feedback loops in gastric cancer and looks forward to their application prospects in the treatment of gastric cancer.