目的 探索基于抗炎饮食的营养治疗在乳腺癌化疗患者中的效果以及对炎性指标、肠道门水平优势菌群及不良事 件的影响。 方法 选取秦皇岛市第二医院 2021 年 2 月至 2024 年 2 月收治的 228 例乳腺癌化疗患者为研究对象,根据随机数字 表法分为两组,对照组 114 例进行常规营养支持,试验组 114 例接受基于抗炎饮食的营养治疗,比较两组干预后 14 d 的炎症 因子水平[白细胞介素-1β(IL-1β)、肿瘤坏死因子(TNF)-α、C 反应蛋白(CRP)]、免疫功能(CD8 + T 细胞、CD4 + T 细胞、CD3 + T 细胞)、营养状况指标[体质指数(BMI)、上臂围(MAC)、肱三头肌皮褶厚度(TSF)]、血清营养指标[前白蛋白(PA)、白蛋白 (Alb)、总蛋白(TP)]、肠道门水平优势菌群(厚壁菌门、变形菌门、拟杆菌门、放线菌门水平)变化,同时,统计两组住院期间不 良事件发生情况。 结果 两组患者干预后 14 d 的 IL-1β、TNF-α、CRP、CD8 + T 细胞、BMI、MAC、TSF 水平以及厚壁菌门、变形菌 门的对数值均低于同组干预前,CD4 + T 细胞、CD3 + T 细胞、PA、Alb、TP 水平以及拟杆菌门、放线菌门的对数值高于同组干预 前,差异具有统计学意义(P<0. 05)。 同时,试验组干预后 14 d 的 IL-1β、TNF-α、CRP、CD8 + T 细胞、CD4 + T 细胞、CD3 + T 细胞、 PA、Alb、TP 较对照组干预后改善效果更优,差异具有统计学意义(P<0. 05),BMI、MAC、TSF 以及厚壁菌门、变形菌门构成比 较对照组干预后更低,差异具有统计学意义(P<0. 05),拟杆菌门、放线菌门构成比较对照组干预后更高,差异具有统计学意义 (P<0. 05)。 同时,试验组不良事件发生率(6. 14% 比 14. 91%)低于对照组,差异具有统计学意义(P<0. 05)。 结论 基于抗炎 饮食的营养治疗在乳腺癌化疗患者中,减轻炎症反应,提高机体免疫功能,改善营养状态,促使整体健康恢复。

Objective To explore the effect of nutritional therapy based on anti-inflammatory diet in breast cancer chemotherapy patients and its effects on inflammatory indicators intestinal gate level dominant flora and adverse events. Method A total of 228 breast cancer chemotherapy patients admitted to Qinhuangdao Second Hospital from February 2021 to February 2024 were selected as the study objects They were divided into two groups according to the random number method. 114 patients in the control group received routine nutritional support and 114 patients in the observation group received nutritional treatment based on anti-inflammatory diet. Compare the inflammatory factor levels leukocyte- 1β IL- 1β tumor cytokines TNF - α C reactive protein CRP immune function CD8 + T cells CD4 + T cells CD3 + T cells nutritional status index body mass index BMI upper arm circumference MAC triceps skinfold thickness TF serum nutrition index prealbumin PA albumin Alb total protein TP dominant flora Firmicutes antibacteria AFP at the same time The occurrence of adverse events during hospitalization was statistically analyzed in two groups. Result After 14 days of intervention the levels of IL-1 β TNF - α CRP CD8 + T cells BMI MAC TSF and the logarithm of Firmicutes and Actinobacteria in both groups were lower than before intervention. The levels of CD4 + T cells CD3 + T cells PA Alb TP and the logarithm of Bacteroidetes and Actinobacteria were higher than before intervention in the same group and the differences were statistically significant P < 0. 05 . At the same time after 14 days of intervention the intervention group showed better improvement in IL-1 β TNF - α CRP CD8 + T cells CD4 + T cells CD3 + T cells PA Alb and TP compared to the control group and the difference was statistically significant P<0. 05 . BMI MAC TSF and the composition of Firmicutes and Actinobacteria were lower in the intervention group compared to the control group and the difference was statistically significant P<0. 05 . The composition of Bacteroidetes and Actinobacteria was higher in the intervention group compared to the control group and the difference was statistically significant P<0. 05 . Meanwhile the adverse events in the intervention group 6. 14% vs 14. 91% were lower than those in the control group and the difference was statistically significant P<0. 05 . Conclusion Nutritional therapy based on anti-inflammatory diet is more feasible safe and scientific. It is used in breast cancer chemotherapy patients to better reduce inflammation improve body immune function improve nutritional status and promote the overall health recovery. It is of great significance for clinical treatment guidance and prognosis improvement and has high utilization value.