化疗作为肝癌患者重要的治疗手段,与分子靶向药物治疗、免疫疗法联合使用,可显著提高治疗效果。 然而,化疗 过程中产生的不良反应会对患者营养状况造成不良影响,进而影响其治疗效果与生活质量,因此,营养治疗在肝癌治疗体系 中占据着重要的地位。 化疗产生的不良反应,如恶心、呕吐、食欲不振等,会直接导致患者摄入营养不足,引发营养不良。 而 营养不良又会进一步降低患者的体力,影响体内总蛋白等关键指标,形成恶性循环,不仅降低了患者对化疗的耐受性,还增加 了治疗风险,降低了生存率。 反之,良好的营养状况能够显著提高患者对化疗的耐受性,增强机体免疫力,对提升治疗效果和 生存率具有积极作用。 在营养评估方面,目前临床上存在多种营养评估工具,如老年营养风险指数(GNRI)、Onodera 预后营 养指数(O-PNI)、控制营养状态评分(CONUT) 等。 结合多种指标进行综合评估,能更全面、准确地反映患者的营养状况,为 后续治疗方案的制订提供更有价值的参考。 正确的营养治疗方案可有效增强患者对化疗的耐受性。 深入研究肝癌患者的营 养状况及营养治疗方法,对于提升肝癌综合治疗效果、改善患者预后具有重要意义。

Chemotherapy as an important treatment method for liver cancer patients when used in combination with molecular targeted drug therapy and immunotherapy can significantly improve the treatment effect. However the adverse reactions during chemotherapy can have an adverse impact on the nutritional status of patients which in turn affects the treatment effect and quality of life. Therefore nutritional therapy occupies an indispensable position in the treatment system of liver cancer. The adverse reactions caused by chemotherapy such as nausea vomiting and loss of appetite can directly lead to insufficient nutrient intake in patients causing malnutrition. Malnutrition can further reduce the physical strength of patients and affect key indicators such as total protein in the body forming a vicious cycle. This not only reduces the tolerance of patients to chemotherapy but also increases the treatment risk and reduces the survival rate. On the contrary a good nutritional status can significantly improve the tolerance of patients to chemotherapy and enhance the body's immunity playing a positive role in improving the treatment effect and survival rate. In terms of nutritional assessment there are currently a variety of nutritional assessment tools in clinical practice such as GNRI O - PNI CONUT etc. Studies have shown that a comprehensive assessment combining multiple indicators can more comprehensively and accurately reflect the nutritional status of patients providing more valuable reference for the formulation of subsequent treatment plans. A correct nutritional treatment plan can effectively enhance the tolerance of patients to chemotherapy. In conclusion in-depth research on the nutritional status and nutritional treatment methods of liver cancer patients is of great significance for improving the comprehensive treatment effect of liver cancer and the prognosis of patients.