肿瘤代谢重编程是肿瘤研究的核心领域之一,其特征为肿瘤细胞通过重塑自身及微环境代谢途径支持恶性增殖与 恶性进展。 近些年来,植物化合物凭借多样化生物活性及多靶点调控能力,逐渐成为干预肿瘤代谢的研究热点。 植物化合物 可通过调节关键代谢酶、抑制异常信号通路、重塑肿瘤微环境等机制,靶向干预肿瘤细胞的代谢重编程,从而抑制肿瘤生长、 转移并增强治疗效果。 本文系统综述了植物化合物在肿瘤代谢调控中的最新研究进展,重点探讨其对糖酵解、氧化磷酸化、 脂质代谢及氨基酸代谢等核心代谢途径的影响,并分析其在肿瘤微环境中的作用机制。 同时总结了植物化合物在临床转化 中递送瓶颈、机制复杂性及转化缺口等挑战。 并基于多组学技术、纳米递送等前沿策略展望未来方向,为植物化合物在肿瘤 防治中的临床应用提供理论依据与转化前景。

Tumor metabolic reprogramming is one of the most critical scientific questions in cancer research which is characterized by tumor cells supporting malignant proliferation and metastasis by remodeling themselves and microenvironmental metabolic pathways. In recent years the potential role of plant compounds for tumor metabolism intervention have been unraveled due to their diverse biological activities and multi-targeting ability. Recent studies have shown that plant compounds is beneficial in the metabolic reprogramming of tumor cells by regulating the activity of critical metabolic enzymes inhibiting aberrant signaling pathways remodeling tumor microenvironment thereby inhibiting tumor growth and metastasis. In this paper we systematically reviewed the latest research of plant compounds in tumor metabolic regulation focusing on their effects on core metabolic pathways such as glycolysis oxidative phosphorylation lipid metabolism amino acid metabolism and analyzed their mechanism of action in tumor microenvironment. We also summarized current challenges for the clinical translation of plant compounds including limited delivery strategies complexed mechanisms etc. Basing on multi - omics technology nano - delivery as well as other cutting - edge technologies we are looking forward to the clinical application of plant compounds in cancer prevention and treatment in the future.