目的 探讨术前血清促血管生成素(Ang-2)、半乳糖凝集素 3(Gal-3)水平在非小细胞肺癌(NSCLC)患者胸腔镜术 后预后评估中的预测价值。 方法 收集无锡市锡山人民医院收治的 2019 年 1 月至 2021 年 1 月行胸腔镜切除术的 NSCLC 患者 92 例为研究对象,根据随访结果分为复发组( n = 34)和非复发组( n = 58)。 血清 Ang-2、Gal-3 水平检测用 ELISA 法,NSCLC 患者血清中 Ang-2 与 Gal-3 水平之间的相关性用 Pearson 法分析;Logistic 回归分析影响 NSCLC 患者预后的相关因素;受试者 操作特征曲线(ROC 曲线)评估血清 Ang-2、Gal-3 水平对 NSCLC 患者预后的预测价值。 结果 与非复发组相比,复发组血清 Ang-2、Gal-3 水平均升高(P<0. 05)。 Pearson 相关性分析结果显示,NSCLC 患者血清 Ang-2 与 Gal-3 水平之间存在明显的正 相关关系(r = 0. 503,P<0. 001)。 复发组和非复发组患者是否有吸烟史、是否有神经侵犯、是否有血管侵袭、病理类型、年龄、 手术中出血量、手术时间比较,差异无统计学意义(P>0. 05),TNM 分期、分化程度比较,差异有统计学意义(P<0. 05)。 TNM 分期,分化程度,血清 Ang-2、Gal-3 水平均是 NSCLC 患者术后复发的影响因素(P<0. 05)。 血清 Ang-2、Gal-3 二者联合预测 NSCLC 患者预后的 AUC 为 0. 965,敏感度为 88. 24%,特异度为 98. 28%,优于 Ang-2、Gal-3 单独预测(Z二者联合-Ang-2 = 3. 221、 P= 0. 001,Z二者联合-Gal-3 = 2. 063、P= 0. 039)。 结论 在 NSCLC 患者中,血清 Ang-2、Gal-3 水平均升高,且可以作为评估 NSCLC 患者胸腔镜切除术后预后的辅助血清标志物。

Objective To explore the predictive value of preoperative serum levels of angiopoietin Ang - 2 and galactin - 3 Gal-3 in the prognosis evaluation of non-small cell lung cancer NSCLC patients after thoracoscopic. Method A total of 92 NSCLC patients who underwent thoracoscopic from January 2019 to January 2021 in our hospital were regarded as the study subjects. According to the follow-up results they were separated into a recurrent group n = 34 and a non recurrent group n = 58 . Serum Ang-2 and Gal-3 levels were detected using ELISA method. The correlation between Ang-2 and Gal-3 levels in the serum of NSCLC patients was analyzed using Pearson 's method. Logistic regression was applied to analyze the relevant factors affecting the prognosis of NSCLC patients. ROC curve was applied to evaluate the predictive value of serum Ang - 2 and Gal - 3 levels for the prognosis of NSCLC patients. Result Compared with the non recurrent group the serum Ang- 2 and Gal- 3 level in the recurrent group increased P< 0. 05 . Pearson correlation analysis results showed a obvious positive correlation between serum Ang-2 and Gal-3 levels in NSCLC patients r = 0. 503 P< 0. 001 . There were no significant differences in smoking history presence of nerve invasion presence of vascular invasion pathological type age intraoperative blood loss or operation time between the recurrence group and the non - recurrence group P>0. 05 . However there was a obvious difference P<0. 05 in TNM staging and differentiation degree. TNM staging differentiation degree serum Ang - 2 and Gal - 3 levels were all influencing factors for postoperative recurrence in NSCLC patients P<0. 05 . The combined prediction of serum Ang-2 and Gal-3 for the prognosis of NSCLC patients had an AUC of 0. 965 sensitivity of 88. 24% and specificity of 98. 28% which was better than Ang-2 and Gal-3 alone prediction Z combination - Ang-2 = 3. 221 P= 0. 001 Z combination - Gal-3 = 2. 063 P= 0. 039 . Conclusion In NSCLC patients serum Ang-2 and Gal-3 levels are elevated and can serve as auxiliary serum markers for evaluating the prognosis of thoracoscopic in NSCLC patients.