摘要
摘要：目的 探讨服用生白固本冲剂能否改善晚期肿瘤患者的营养状况及疲乏程度。 方法 观察性分析自 2015 年 2 月24 日至 2016 年 6 月 18 日期间在我院接受疼痛治疗且服用生白固本冲剂大于 2 周的晚期肿瘤患者共计 37 例，分别采用BFI-C 评分、 MFI-20 评分、 PG-SGA 评分以及白蛋白水平、握力、膳食摄入量等指标评价服用生白固本冲剂前后患者营养状况和疲乏程度的改变情况。 结果 患者治疗前 BFI-C 综合疲乏程度评分为 4.57±2.26，治疗后为 2.62±1.93，治疗前后评分改变有统计学差异（P=0.000），同样，患者治疗后 BFI-C 综合疲乏程度评分明显低于治疗前（P=0.001）；患者治疗后MFI-20 体力疲乏评分（P=0.001）、脑力疲乏评分（P=0.003）均明显低于治疗前；患者治疗后 PG-SGA 评分亦明显低于治疗前（10.54 vs 12.17， P=0.001）；患者治疗前能量摄入均值为 786.49 kcal，治疗后能量摄入均值为 1002.70 kcal，治疗前后均值改变有统计学差异（P=0.000）。 结论 晚期肿瘤患者服用生白固本冲剂能缓解患者疲乏程度，增加患者能量摄入，改善营养状况，但尚需大样本临床试验进一步验证。
Abstract
Abstract: Objective The aim of this study was to discuss whether Shengbai Guben granule can improve the nutritional status and the degree of fatigue in advanced cancer patients. Methods From February 24, 2015 to June 18, 2016, 37 patients who received pain management and oral Shengbai Guben granule therapy more than 2 weeks were observed. The change of nutritional status and the degree of fatigue were evaluated by BFI-C, MFI, PG-SGA, albumin level, grip strength, and daily intake. Results The mean score of the degree of BFI-C before treatment was 4.57 and the score was 2.26 after treatment, the score has significant difference
(P=0.001). Similarly, the score of the effect of BFI-C after treatment were significant lower than pre-treatment (P=0.001). The score of MFI mental fatigue (P=0.001), brain fatigue (P=0.003) after treatment were also lower than pre-treatment. The PG-SGA score after treatment was also lower than pre-treatment (10.54 versus 12.17, P=0.001). The mean energy intake before treatment and after treatment has significant difference (P=0.000). Conclusions Oral Shengbai Guben granule can relief the degree of fatigue, and increase the energy intake and improve the nutritional status, however, it needs further study.
关键词
晚期肿瘤 /
营养治疗 /
疲乏 /
生白固本冲剂
Key words
Advanced cancer /
Nutrition therapy /
Fatigue /
Shengbai Guben granule
曾亚奇;刘维帅;王昆.
生白固本冲剂治疗晚期肿瘤患者的疗效观察[J]. 肿瘤代谢与营养电子杂志. 2016, 3(3): 174-177 https://doi.org/10.16689/j.cnki.cn11-9349/r.2016.03.012
ZENG Ya-qi;LIU Wei-shuai;WANG Kun.
The clinical effect of Shengbai Guben granule in advanced cancer patients[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2016, 3(3): 174-177 https://doi.org/10.16689/j.cnki.cn11-9349/r.2016.03.012
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基金
国家临床重点专科建设项目经费资助（2013-544）
国家自然科学基金项目（81201065）
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