mTOR 通路基因甲基化与肿瘤能量代谢

李洁茹; 马怀幸; 李苏宜

doi:10.16689/j.cnki.cn11-9349/r.2016.03.014

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肿瘤代谢与营养电子杂志 ›› 2016, Vol. 3 ›› Issue (3) : 186-190. DOI: 10.16689/j.cnki.cn11-9349/r.2016.03.014

综述

mTOR 通路基因甲基化与肿瘤能量代谢

作者信息 +

The methylation of gene in mTOR pathway and tumor energy metabolism

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摘要

摘要： mTOR 在接受生长因子和激素等信号刺激后，调节细胞增殖与分化。本文综合分析文献后认为， mTOR 信号通
路关键节点基因甲基化致肿瘤组织发生能量异常代谢，引起肿瘤有氧糖酵解增强，并干扰蛋白质水解。 mTOR 通路节点基
因去甲基化或许是逆转肿瘤组织能量异常代谢的切入点。

Abstract

Abstract: Stimulated by growth factors, hormone and other signals, mTOR plays a critical role in regulating cell proliferation
and differentiation. We reviewed and analyzed literatures, then argued that the methylation of key genes in mTOR signaling pathway
could result in abnormal energy metabolism in cancer, producing aerobic glycolysis, and interfering with protein hydrolysis.
Demethylating genes in mTOR signaling pathway, which might be an entry point to reverse the abnormal energy metabolism in
cancer.

导出引用

李洁茹;马怀幸;李苏宜. mTOR 通路基因甲基化与肿瘤能量代谢[J]. 肿瘤代谢与营养电子杂志. 2016, 3(3): 186-190 https://doi.org/10.16689/j.cnki.cn11-9349/r.2016.03.014

LI Jie-ru;MA Huai-xing;LI Su-yi. The methylation of gene in mTOR pathway and tumor energy metabolism[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2016, 3(3): 186-190 https://doi.org/10.16689/j.cnki.cn11-9349/r.2016.03.014