药物在机体内将受到各种因素的影响，随着人类食物品种的增加和饮食结构的多样性，食物愈加成为不可忽视 的影响因素，特别是口服药物进入人机体后，可能首先在消化道与食物发生各种物理、化学反应，并影响药物在体内的生 物转化和利用，即通过药物药动学和药效学的变化，从而导致药物治疗结局的改变。药物亦可能影响食欲，干扰体内营养 物质的吸收和利用，从而导致营养物质紊乱或失衡。目前，这一领域日益受到关注，本文介绍了食物与药物相互作用的分类、 发生部位、一些食物，特别是葡萄柚汁及其他一些果汁，经肠道CYP3A 酶系的抑制通路对药物代谢的影响、药物对食 物吸收、代谢、排泄的影响以及常见口服抗肿瘤药物与食物的相互作用实例及服用注意事项。临床医护人员和药师应了解 和掌握常见的食物与药物相互作用的基本知识和常见实例，对患者进行合理的用药宣教，避免在用药时服用已知的可发生相互作用的食物，减少由于饮食不当引起的药源性损害或治疗失败，达到治疗效果的最优化。

Drugs will be affected by various factors in the body, with the increasing of human food varieties and the diversity of dietary structure, food has increasingly become a factor that can not be ignored, especially oral drugs. It may occur in the astrointestinal tube firstly by various physical and chemical reactions, and then affect the PK and PD of the drug, leading to changes in drug treatment outcoming. Equally, drugs may also affect the appetite and the absorption and utilization of the food and nutrients, leading to nutrient disorder or imbalance. Now people take more attention on this area. This paper introduces the classification and occurrencing lacation of the interaction between food and drug, some food, especially grapefruit juice and some other fruit juice, affecting the inhibitory pathway of the CYP3A enzyme system on the drug metabolism, and the effect of the drug on the absorption, metabolism and excretion of food, and the common interaction of oral antitumor drugs and food and the cautions for use . Clinical medical staff and pharmacists should understand and master the basic knowledge and common examples of food and drug interactions, educate patients about rational use of drugs, avoiding taking interacting foods, which could reduce the drug induced damage or treatment failure due to improper diet and achieve the optimal treatment effect.