癌性疼痛（癌痛）是指肿瘤、肿瘤相关症状或抗肿瘤治疗所致的疼痛，其发生发展与机体营养代谢情况密切相关。 癌痛可从饮食摄入、神经内分泌系统、社会心理等途径影响机体的营养代谢；反过来，机体多种营养物质如维生素类、镁 元素及咖啡因、姜黄素、辣椒素、多不饱和脂肪酸（polyunsaturated fatty acid，PUFA）等的变化亦会通过多种机制对癌 痛产生一定影响 ；另外，肿瘤细胞的异常代谢，如谷氨酸和甲醛含量的增加参与了癌痛的发生发展过程，其中，谷氨酸含量 的升高主要由于肿瘤细胞内氧化 - 还原系统失衡和谷氨酰胺（glutamine， Gln）代谢水平增高所致，进而通过介导瞬时受体电 位阳离子通道亚家族 V 成员 1（transient receptor potential cation channel subfamily V member 1，TRPV1）促使伤害性信号持续性 传导。本文主要对癌痛与营养代谢之间的相互影响以及肿瘤代谢产物引发癌痛的相关机制进行综述，并提出了针对癌痛患者 的营养治疗对策。

Cancer pain refers to tumor, tumor-related symptoms or the pain caused by anti-tumor treatment, and that the occurrence and development of cancer pain are closely related to the nutritional metabolism of the body. Cancer pain affects the body's nutritional metabolism through dietary intake, neuroendocrine system, social psychosocial and so on. In turn, the changes in the body's various nutrients, including vitamins, magnesium and caffeine, curcumin, capsaicin, polyunsaturated fatty acid (PUFA), etc. also have certainly impacts on cancer pain through multiple mechanisms. In addition, abnormal metabolisms of tumor cells are involved in the genesis and development of cancer pain.Among them, the increase of glutamate content is mainly due to the imbalance of oxidation-reduction system in tumor cells and the increase  metabolic level of glutamine (Gln) , and then glutamate promotes persistent transmission of nociceptive signals though mediating transient receptor potential cation channel subfamily V member 1 (TRPV1). This article mainly reviews the interaction between cancer pain and nutrient metabolism, as well as mechanisms related to tumor metabolites causing cancer pain, finally proposes nutrition therapy for patients with cancer pain.