目的  探讨 miR-10a 及 let-7i 在子宫内膜癌组织中的表达及意义。方法  选取子宫内膜癌组织40 例、子宫内膜不 典型增生组织20例及正常子宫内膜组织30例，采用多聚腺苷酸加尾实时荧光定量逆转录聚合酶链反应[poly（A）-RT-qPCR] 测定miR-10a 及 let-7i 在三种子宫内膜组织中的表达，并将结果与临床及病理资料进行分析。结果  miR-10a 在子宫内膜癌 组织中高表达（高于正常及不典型增生的子宫内膜组织，P＜0.01）；在病理分级为3级的患者中高表达（高于1+2级者）； 在Ⅲ+Ⅳ期患者中高表达（高于Ⅰ+Ⅱ期者）；在有淋巴结转移的患者中高表达，在深肌层浸润（浸润深度≥1/2）的患者 中高表达；差异显著（P ＜ 0.05）。在不同年龄、雌激素受体（ER）及孕激素受体（PR）是否阳性的子宫内膜癌患者中其 表达量差异无统计学意义（P ＞ 0.05）。let-7i 在子宫内膜癌组织低表达（低于正常和不典型增生的子宫内膜组织，P ＜ 0.01）。结论  在子宫内膜癌组织中miR-10a 表达上调，let-7i 表达下调，miR-10a 可能参与并促进了子宫内膜癌的侵袭 和转移。

 Objective  To investigate the expression of miR-10a and let-7i in endometrial carcinoma tissues and its significance. Methods  Forty cases of endometrial carcinoma，twenty cases of atypical hyperplasia and thirty cases of normal endometrium tissues were collected, poly (A)-RT-qPCR was employed to test the expression of miR-10a and let-7i in different endometrial tissues. The statistical analyses were performed between the expression of miR-10a and let-7i and the clinicopathological characteristics. Results  The expression of miR-10a was higher in endometrial carcinoma tissues than that of normal endometrium and atypical hyperplasia tissues (P<0.01). The expression of miR-10a in patients with grade 3 of pathology was higher than that 1+2, in stage Ⅲ+Ⅳof endometrial carcinoma patients was higher than stageⅠ+Ⅱ, in patients with lymph node metastasis was higher than that without lymph node metastasis , in patients that myometrial invasion≥1/2 was higher than that<1/2. The expression of miR10a in different age, whether ER-positive, PR-positive had no statistical difference (P>0.05).  The expression of let-7i was lower in endometrial carcinoma tissues than that of normal endometrium and atypical hyperplasia tissues (P<0.01)。Conclusions  In endometrial carcinoma tissues, the expression of miR-10a was up-regulated, let-7i was down-regulated, miR-10a may promote invasion and metastasis of endometrial carcinoma.