随着现代社会的高速发展，人类肿瘤的发病率逐年升高，严重威胁人类健康，关于肿瘤的研究也越来越多，其 中不乏线粒体DNA（mtDNA）与肿瘤的相关研究，尤其近几年来，mtDNA 与肿瘤的研究已经逐渐成为肿瘤研究的热点。 mtDNA 的研究涉及点突变、片段缺失、含量的变化等方面。本文综合整理mtDNA 含量在肿瘤中的相关研究，查阅近10 年的国内外mtDNA 含量在不同肿瘤中相关研究文献资料，找出其研究的方式、方法及得到的相关资料、数据进行归纳、 分析、总结，发现肿瘤中mtDNA 含量相关研究较多，研究的肿瘤类型多样，并涉及不同肿瘤的发生、发展、治疗及预后 等多方面，不同研究的结果不尽相同，甚至有相反的结果。但大量研究显示：肿瘤的发生、发展中均有 mtDNA 含量的变 化，mtDNA 含量变化对肿瘤发生、发展及治疗、预后等方面均有影响，mtDNA 含量的变化在不同肿瘤中及肿瘤的不同阶 段发挥作用的方式等各不相同，其发挥作用的机理多样，这些研究资料为后期肿瘤中mtDNA含量相关研究提供理论参考， 有望为肿瘤的诊治做出一定贡献。

 With the rapid development of modern society, the incidence of human tumors has been increased year by year, posing a serious threat to human health. There are more and more researches on tumors, among which there are many studies on mitochondrial DNA(mtDNA) and tumor. Especially in recent years, the research on mtDNA and tumor has gradually become the focus of tumor research. MtDNA research involves point mutation, fragment deletion, content change and so on. This paper comprehensively collated the relevant research on mtDNA content in tumors, reviewed the relevant research literature on mtDNA content in different tumors at home and abroad in past 10 years, found out the research methods and relevant data and data obtained for induction, analysis and summary. It is found that there are many studies on mtDNA content in tumors, and the types of tumors studied are diverse, involving the occurrence, development, treatment and prognosis of different tumors. The results of different studies are not the same, or even the opposite. However, a large number of studies have shown that mtDNA content changes in the occurrence and development of tumors, and mtDNA content changes have  impacts on the occurrence, development, treatment and prognosis of tumors and so on. mtDNA content changes play a different role in different tumors and at different stages of tumors, and the mechanisms are diverse. These research data provide theoretical reference for the related studies of tumor  mtDNA content in the future, and it is expected to make contributions to the diagnosis and treatment of tumor.