雷公藤红素与肿瘤代谢的关系研究进展

李晔; 宋蒙蒙; 常文军; 缪明永; 潘亚敏

doi:10.16689/j.cnki.cn11-9349/r.2020.01.004

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肿瘤代谢与营养电子杂志 ›› 2020, Vol. 7 ›› Issue (1) : 18-21. DOI: 10.16689/j.cnki.cn11-9349/r.2020.01.004

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雷公藤红素与肿瘤代谢的关系研究进展

1李晔，2宋蒙蒙，3常文军，4缪明永，1潘亚敏

作者信息 +

Research progress on the relationship between celastrol and tumor metabolism

1 Li Ye,2 Song Mengmeng,3 Chang Wenjun,4 Miao Mingyong,1 Pan Yamin

Author information +

文章历史 +

摘要

雷公藤红素是一种中草药活性成分，具有广泛的治疗特性及较高的药用价值，通常用于治疗自身免疫性疾病、代谢性疾病及肿瘤。雷公藤红素可以通过多种途径抑制肿瘤的发生、发展，尤其与肿瘤代谢密切相关，对肿瘤细胞的糖代谢、脂类代谢、氨基酸代谢及肿瘤微环境产生重要影响。雷公藤红素导致线粒体功能障碍以改变葡萄糖代谢途径，使肿瘤细胞供能不足；通过诱导肝内Sirt1的表达影响肿瘤宿主的脂类代谢；抑制吲哚胺2，3双加氧酶（IDO）表达和色氨酸分解代谢来抑制结直肠癌，与IDO的抑制剂D-1MT联用控制胰腺癌；在肿瘤微环境中，雷公藤红素可通过抑制NLRP3炎性小体及重塑免疫抑制治疗黑色素瘤。根据最新研究报道，肠道菌群的高度代谢可以提高雷公藤红素在体内的功效，影响肿瘤发展。本文从代谢的角度阐述雷公藤红素对肿瘤的主要作用及机制，为其药理作用的深入研究提供科学依据。

Abstract

Celastrol is an active ingredient of Chinese herbal medicine with extensive therapeutic properties and high medicinal value. It is commonly used in the treatment of autoimmune diseases, metabolic diseases and cancer. Celastrol can inhibit the occurrence and development of tumor through a variety of ways, especially closely related to tumor metabolism, and has an important impact on the metabolism of sugar metabolism, lipid metabolism, amino acid metabolism and tumor microenvironment of tumor cells. Celastrol causes mitochondrial dysfunction to alter the glucose metabolism pathway, resulting in insufficient energy supply to tumor cells； affects lipid metabolism in tumor hosts by inducing liver Sirt1 expression； inhibits the progress of colorectal cancer by inhibiting indoleamine 2,3 dioxygenase (IDO) expression and tryptophan catabolism, controls pancreatic cancer by combining with IDO inhibitor D-1MT. In the tumor microenvironment, celastrol can treat melanoma by inhibiting NLRP3 inflammatory bodies and remodeling immunosuppression. According to the latest research, the high metabolism of intestinal flora can improve the efficacy of celastrol in the body, affecting the development of tumors. This review describes the main effects and mechanisms of celastrol on tumors from a metabolic perspective, providing a scientific basis for its in-depth study of pharmacological effects.

导出引用

李晔，宋蒙蒙，常文军，缪明永，潘亚敏. 雷公藤红素与肿瘤代谢的关系研究进展[J]. 肿瘤代谢与营养电子杂志. 2020, 7(1): 18-21 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.01.004

Li Ye,Song Mengmeng,Chang Wenjun,Miao Mingyong,Pan Yamin. Research progress on the relationship between celastrol and tumor metabolism[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(1): 18-21 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.01.004

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