术后PNI在胃癌患者预后评估中的临床价值

吴平; 杜仁佳; 俞筠; 葛晓松

doi:10.16689/j.cnki.cn11-9349/r.2020.03.012

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肿瘤代谢与营养电子杂志 ›› 2020, Vol. 7 ›› Issue (3) : 312-316. DOI: 10.16689/j.cnki.cn11-9349/r.2020.03.012

论著

术后PNI在胃癌患者预后评估中的临床价值

吴平1，杜仁佳1，俞筠1，葛晓松2

作者信息 +

Clinical value of postoperative PNI in prognosis assessment of gastric cancer patients

Wu Ping1, Du Renjia1, Yu Yun1,Ge Xiaosong2

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摘要

目的探讨术后PNI在胃癌患者预后评估中的临床价值。方法回顾性分析术后胃癌Ⅲ期患者91例，根据术后、首次化疗前的外周血液指标计算出PNI、外周血中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、全身炎症指数（SII）等营养综合指标，通过ROC曲线计算出PNI最佳截断值。根据PNI最佳截断值将其分为低PNI组（PNI<42.3）和高PNI组（PNI≥42.3），根据PNI分组预测胃癌患者的预后。应用Cox回归模型进行单因素回归分析和多因素分析。结果多因素分析结果显示术后PNI（P=0.004）及分期（P=0.009）是影响胃癌患者总生存时间的独立预后因素。结论术后PNI是预测胃癌患者预后的独立因素，且低PNI和高分期与患者预后不良相关。

Abstract

Objective The prognostic nutritional index(PNI) is used as a prognostic factor in gastric cancer(GC). Through this retrospective study, we aim to investigate the relationship between the postoperative PNI and prognosis of patients with stage Ⅲ GC. Methods The subjects of this retrospective study were 91 patients who underwent resection for stage Ⅲ GC, according to the first chemotherapy after surgery, calculated nutrient comprehensive index, such as PNI, NLR, PLR, SII. Time-dependent receiver operating characteristic curve analyses were used to assess discrimination ability and to determine the optimal cut-off values. Results According to the optimal cut-off value, they were divided into the low PNI group (PNI<42.3) and the high PNI group (PNI≥42.3).According to the staging, they were divided into Ⅲa, Ⅲb and Ⅲc three substages. All the inflammation-based and/or the nutritional markers of patients of stage Ⅲ GC, multivariate analyses demonstrated PNI and staging were independent prognostic factors for OS (P=0.004 and P=0.009, respectively). Conclusion PNI is an independent prognostic factor for the prognosis of postoperative chemotherapy patients with gastric cancer, and low PNI and high sub-staging were associated with poor prognosis.

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吴平，杜仁佳，俞筠，葛晓松. 术后PNI在胃癌患者预后评估中的临床价值[J]. 肿瘤代谢与营养电子杂志. 2020, 7(3): 312-316 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.03.012

Wu Ping, Du Renjia, Yu Yun,Ge Xiaosong. Clinical value of postoperative PNI in prognosis assessment of gastric cancer patients[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(3): 312-316 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.03.012

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