黄酮类化合物及其纳米制剂在肿瘤防治中的研究进展

doi:10.16689/j.cnki.cn11-9349/r.2020.03.021

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肿瘤代谢与营养电子杂志 ›› 2020, Vol. 7 ›› Issue (3) : 362-365. DOI: 10.16689/j.cnki.cn11-9349/r.2020.03.021

综述

黄酮类化合物及其纳米制剂在肿瘤防治中的研究进展

高慧1，付强2，孙洁1，左学志1，姚颖1

作者信息 +

Research progress of flavonoids and their nanocrystals in tumor prevention and treatment

Gao Hui1, Fu Qiang2, Sun Jie1, Zuo Xuezh1, Yao Ying1

Author information +

文章历史 +

摘要

传统的肿瘤治疗方法依然存在肿瘤组织可及性差和药物不良反应普遍的问题。黄酮类化合物已被证实对多种类型肿瘤有效，但其安全性和作用部位特异性尚未被评估。然而，膳食黄酮类化合物因溶解度小、代谢快、口服吸收差等特点限制了其在体内抗肿瘤活性的发挥。此外，黄酮类化合物在某些情况下还能通过生物转化等作用与药物相互作用而影响生物利用度。纳米载体因可改变药物的药动学和药效学特征而被设计用于靶向药物传递，提高难溶性药物的生物利用度，将大分子传递到细胞内的作用位点，同时还能减少药物不良反应。体内、外研究均表明，纳米类黄酮制剂，特别是槲皮素、柚皮素、芹菜素、儿茶素和非瑟酮等在多种肿瘤的预防和治疗方面具有潜在作用，但其临床应用价值仍有待阐明。本文就纳米类黄酮制剂在提高生物利用度、肿瘤治疗效果和安全性方面的作用展开综述，为肿瘤治疗药物的开发利用提供新思路。

Abstract

The poor accessibility to tumor tissues and a range of adverse drug reactions are still great concerns for cancer therapies. Flavonoids are documented great potential in combating various types of cancer, while their safety profile and tumor site-specific action have not been evaluated thoroughly. Low solubility, rapid metabolism and poor absorption of dietary flavonoids limit their antitumor activity in vivo. Moreover, flavonoids may interact with other therapeutic agents resulting their bioavailability reduction, especially through biotransformation. Nanocarriers can alter pharmacokinetics and pharmacodynamic profile of incorporating drug. Moreover, nanocarriers are designed for targeted drug delivery, improving the bioavailability of poorly water-soluble drugs, delivery of macromolecules to site of action, and reducing ADRs. It has been shown the potential of flavonoids nano-formulations, especially quercetin, naringenin, apigenin, catechins and fisetin in the prevention and treatment of several types of cancer, both in vitro and in vivo studies. However, few clinical trials have yet to be performed. This review focuses on the impact of flavonoids nano-formulations on the improvement of their bioavailability, therapeutic and safety profile and will open new insights in the field of drug discovery for cancer therapeutics.

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高慧，付强，孙洁，左学志，姚颖. 黄酮类化合物及其纳米制剂在肿瘤防治中的研究进展[J]. 肿瘤代谢与营养电子杂志. 2020, 7(3): 362-365 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.03.021

Gao Hui, Fu Qiang, Sun Jie. Zuo Xuezh, Yao Ying. Research progress of flavonoids and their nanocrystals in tumor prevention and treatment[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2020, 7(3): 362-365 https://doi.org/10.16689/j.cnki.cn11-9349/r.2020.03.021

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