红树莓生物活性成分的药理作用研究进展

张浩鹏; 吕强; 刘明

doi:10.16689/j.cnki.cn11－9349/r.2019.04.002

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肿瘤代谢与营养电子杂志 ›› 2019, Vol. 6 ›› Issue (4) : 396-400. DOI: 10.16689/j.cnki.cn11－9349/r.2019.04.002

专家论坛

红树莓生物活性成分的药理作用研究进展

张浩鹏，吕强，刘明

作者信息 +

Research progress on pharmacological activities of bioactive constituents of red raspberry

ZHANG Hao-peng, LV Qiang, LIU Ming

Author information +

文章历史 +

摘要

红树莓是蔷薇科悬钩子属类植物，其含有多种营养成分及多种生物活性物质，对人体健康有益，因此被称为黄金水果。长期食用红树莓可以降低罹患多种慢性疾病的风险并起到治疗作用。红树莓及其活性成分能够抑制氧化应激、减轻炎症反应、调节内皮功能，从而起到减缓或者治疗心、脑血管系统疾病的作用。红树莓能通过抑制α-淀粉酶和α-葡萄糖苷酶的活性，减少餐后葡萄糖的吸收。红树莓含有大量的膳食纤维和酚类活性物质，能够调节脂类代谢。抗炎作用机制主要是减少低密度脂蛋白（Low-density lipoprotein，LDL）及脂质的氧化、DNA损伤、活性氧（Reactive Oxygen Species, ROS）、及一氧化氮（Nitric Oxide,NO）的产生、增加抗氧化物酶活性。抗肿瘤机制主要包括清除ROS以防止DNA氧化损伤、抑制DNA加合物的形成、加强DNA修复能力，以及调节细胞增殖、凋亡等信号通路。本文对红树莓在心、脑血管疾病，糖尿病，肥胖，炎症，肿瘤等疾病中的药理作用进行综述。

Abstract

The red raspberry is a rubus of the rose family. It contains varieties of nutrients as well as biological active substances, and is beneficial to human health. Therefore, its called the golden fruit. Long-term consumption of red raspberries can reduce the risk of many chronic diseases and play therapeutic roles. Oxidative stress and inflammatory reaction can be inhibited by red raspberry. And it can also regulate endothelial function. Thus, it retards or treats cardiovascular and cerebrovascular diseases. Inhibiting the activity of α-amylase and α-glucosidase, red raspberry can reduce the absorption of glucose after meals. Red raspberry contains a lot of dietary fiber and phenolic active substances, which can regulate lipid metabolism. Anti-inflammatory effects are mainly achieved by reducing LDL and lipid oxidation, DNA damage, the production ROS, and NO, and increasing antioxidant enzyme activity. Antitumor mechanism mainly includes the scavenging ROS to prevent DNA oxidative damage, inhibiting the formation of DNA adduct, strengthening the DNA repair capacity, as well as regulating cell proliferation, apoptosis signaling pathways. This article reviews the pharmacological roles of red raspberry in heart cardiovascular and cerebrovascular diseases, diabetes, obesity, inflammation, tumor and other diseases.

导出引用

张浩鹏，吕强，刘明. 红树莓生物活性成分的药理作用研究进展[J]. 肿瘤代谢与营养电子杂志. 2019, 6(4): 396-400 https://doi.org/10.16689/j.cnki.cn11－9349/r.2019.04.002

ZHANG Hao-peng, LV Qiang, LIU Ming. Research progress on pharmacological activities of bioactive constituents of red raspberry[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2019, 6(4): 396-400 https://doi.org/10.16689/j.cnki.cn11－9349/r.2019.04.002

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