目的探讨食管肿瘤与头颈部肿瘤患者在调强放疗期间营养状况和生活质量的相关性。方法选取2018年11月至2019年5月肿瘤放疗患者进行研究，采用NRS 2002和PG-SGA对患者进行营养评估，运用EORTC QLQ-C30进行生活质量测评，并分析两者之间相关性。结果41例患者中食管肿瘤23例，头颈部肿瘤18例，放疗后体重丢失35例，占85.36%，其中丢失≥5%体重患者19例，占46.34%，体重丢失>10%患者2例，占4.88%，平均丢失体重3.6kg。41例患者中合并骨髓抑制31例、低蛋白血症15例，电解质紊乱24例。放疗后，41例患者在总健康水平及功能方面得分均低于放疗前（P<0.05），症状方面如疼痛、疲倦、食欲丧失等得分均高于放疗前（P<0.05）。总健康水平、躯体功能、疼痛和食欲丧失等方面与营养状况存在明显相关性（P<0.05）；而社会功能、情绪功能、气促和便秘与营养状况无明显相关性（P>0.05）。结论肿瘤患者在放疗期间的营养状况和生活质量存在相关性，应重视肿瘤放疗患者的营养评估及干预，改善患者躯体功能、疼痛、食欲等方面的生活质量，从而提高放疗效果。
Abstract
Objective To investigate the correlation between nutritional status and quality of life in esophageal tumors and head and neck tumors during intensity-modulated radiotherapy. Methods The cancer patients who received radiotherapy from November 2018 to May 2019 were selected for the study. NRS 2002 and PG-SGA were used to evaluate the nutrition of the patients during radiotherapy, and EORTC QLQ-C30 was used to evaluate the quality of life, and the correlation between them was analyzed. ResultsA total of 41 patients were enrolled, including 23 cases of esophageal cancer and 18 cases of head and neck cancer. 35 cases （85.36%） lost weight after radiotherapy, of which 19 cases （46.34%） lost ≥ 5% body weight. There were 2 patients with weight loss>10%, accounting for 4.88%, and the average weight loss was 3.6kg. During radiotherapy, there were 31 patients with myelosuppression, 15 patients with hypoalbuminemia and 24 patients with electrolyte disorder. After radiotherapy, The scores of general health status and physical function of patients were lower than those before radiotherapy （P<0.05）. The scores of pain, fatigue and loss of appetite were higher than those before radiotherapy （P<0.05）. General health status, physical function, pain and loss of appetite were significantly correlated with nutritional status （P<0.05）, while social function, emotional function, shortness of breath, constipation showed no significant correlation with nutritional status （P>0.05）. ConclusionThe nutritional status of cancer patients during radiotherapy is correlated with their quality of life. Attention should be paid to the nutritional evaluation and intervention during radiotherapy, in order to improve the quality of life in terms of physical function, pain and appetite and efficacy of cancer patients.
关键词
肿瘤 /
调强放疗 /
营养状况 /
生活质量
Key words
Cancer /
Intensity-modulated radiotherapy /
Nutritional status /
Quality of life
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基金
军委后勤保障部卫生局面上项目（17BJZ47）
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