CT相关骨骼肌参数在胃肠道肿瘤中的临床进展

1李怡; 2周福祥; 1李秦阳; 1胡科; 1刘先昊; 1徐祎骏; 1; 3于常华

doi:10.16689/j.cnki.cn11－9349/r.2019.04.020

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肿瘤代谢与营养电子杂志 ›› 2019, Vol. 6 ›› Issue (4) : 494-498. DOI: 10.16689/j.cnki.cn11－9349/r.2019.04.020

综述

CT相关骨骼肌参数在胃肠道肿瘤中的临床进展

1李怡，2周福祥，1李秦阳，1胡科， 1刘先昊，1徐祎骏，1，3于常华

作者信息 +

Research progress of CT relevant parameters in patients with gastrointestinal cancers

1LI Yi, 2ZHOU Fu-xiang, 1LI Qin-yang, 1 HU Ke, 1LIU Xian-hao, 1XU Yi-jun, 1,3YU Chang-hua

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文章历史 +

摘要

研究表明骨骼肌质和量的退化和胃肠道肿瘤患者临床结局密切相关。CT为肿瘤患者常用临床诊疗工具，其对骨骼肌具有较高分辨率。CT相关参数“SMD和SMI”可分别反映骨骼肌质（肌肉脂肪浸润，myosteatosis）和量（肌肉减少症，sarcopenia）的变化。本文以“肌肉减少症、肌肉脂肪浸润、骨骼肌指数、骨骼肌密度、肿瘤、预后、治疗不良反应”等为关键词检索Pubmed及CNKI相关文献总结CT相关参数在胃肠道肿瘤患者中临床应用价值。结果发现：肌肉脂肪浸润（低SMD）及肌肉减少症（低SMI）在胃肠道肿瘤患者中发生率均较高，且两者评估标准渐趋统一，但最佳截断值仍具有争议。肌肉脂肪浸润（低SMD）及肌肉减少症（低SMI）均可降低胃肠道肿瘤患者治疗耐受性，且均为胃肠道肿瘤患者不良预后因素。综上所述，CT相关骨骼肌参数可协助指导胃肠道肿瘤患者的诊疗决策及预后判断，具有重要临床应用价值。

Abstract

The degeneration of skeletal muscle is closely related to clinical outcomes of patients with carcinomas. CT is one of the commonly used diagnostic tools for patients with cancers, with high resolutions for skeletal muscles. The CT relevant parameters-SMD （skeletal muscle density） and SMI （skeletal muscle index）-reflect the quality （myosteatosis） and quantity （sarcopenia） for skeletal muscle. In this article, we collected literatures home and abroad through “pubmed and CNKI” to explore the clinical values of SMD and SMI among patients with gastrointestinal cancers. It was found that incidences of myosteatosis （low SMD） and myosteatosis （low SMI） are high, and the evaluation standards are gradually unified. However, the best cut-off value for myosteatosis （low SMD） and myosteatosis （low SMI） is still controversial. Furthermore, both myosteatosis （low SMD） and myosteatosis （low SMI） are associated with poorer treatment tolerance and clinical outcomes. In all, CT relevant parameters provide efficient tools in diagnosis and prognosis prediction for patients with gastrointestinal cancers, with important clinical application value.

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Key words

CT relevant skeletal muscle parameters

/ Skeletal muscle density / Myosteatosis / Skeletal muscle index / Sarcopenia / Prognosis

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1李怡，2周福祥，1李秦阳，1胡科， 1刘先昊，1徐祎骏，1，3于常华. CT相关骨骼肌参数在胃肠道肿瘤中的临床进展[J]. 肿瘤代谢与营养电子杂志. 2019, 6(4): 494-498 https://doi.org/10.16689/j.cnki.cn11－9349/r.2019.04.020

1LI Yi, 2ZHOU Fu-xiang, 1LI Qin-yang, 1 HU Ke, 1LIU Xian-hao, 1XU Yi-jun, 1,3YU Chang-hua. Research progress of CT relevant parameters in patients with gastrointestinal cancers[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2019, 6(4): 494-498 https://doi.org/10.16689/j.cnki.cn11－9349/r.2019.04.020

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