摘要：目的 探讨中国大陆合并 2 型糖尿病乳腺癌患者临床特征及预后。 方法 检索 2000~2014 年 Cochrane 图书馆、 Embase 数据库、 Pubmed、 CNKI 数据库、万方数据库、维普数据库，收集有关罹患 2 型糖尿病中国大陆乳腺癌患者临床 特征及预后病例对照研究。采用 RevMan 5.2 软件进行文献数据综合。根据异质性大小采用固定或随机效应模型。 结果 14 项研究符合纳入标准，包括 3711 例患者（实验组 1106 例，对照组 2605 例）。两组人群临床分期（III-IV）、 T 分期（T3- T 4）、复发转移率、死亡率的风险比（risk ratio， RR）分别为 1.77（95%CI=1.37-2.3， P<0.0001）、 1.57（95%CI=1.19- 2.08 ， P=0.001）、 1.93（95%CI=1.56-2.39， P<0.00001）、 1.64（95%CI=1.18-2.28， P=0.03）。两组人群年龄均数差（mean difference ， MD） 3.47（95%CI=2.64-4.29， P=0.001）。实验组较对照组临床分期、 T 分期更晚，其他临床特征方面无统计 学意义。 结论 与非罹患 2 型糖尿病的乳腺癌患者相比，合并 2 型糖尿病的乳腺癌患者年龄更大，临床分期和 T 分期较晚， 复发转移率及死亡率均较高，预后更差。

Abstract: Objective To investigate clinical features and prognosis of breast cancer patients with type-2 diabetes mellitus in mainland China. Methods A systematic search of Cochrane library, Pubmed, EMBASE, CNKI, Wanfang and VIP from 2000 to 2014 was conducted. Case control studies combined with clinical features and prognosis of breast cancer patients with type 2 diabetes mellitus in mainland China were collected. RevMan 5.2 was used to synthesize literature data. Fixed-effect or random effects model was adopted according to heterogeneity. Results 14 studies met the inclusion criteria, including 3711 cases of patients (study group 1106 cases, 2605 cases in the control group). Diabetes was positively associated with later clinical stage (III-IV) and T stage (T3- T 4), higher recurrence rate and mortality rate 1.77 (95%CI=1.37-2.3, P<0.0001), 1.57 (95%CI=1.19-2.08, P=0.001), 1.93 (95% CI=1.56-2.39, P<0.00001), 1.64 (95%CI=1.18-2.28, P=0.03). The mean difference (mean difference, MD) for average age was 3.47 (95%CI=2.64-4.29, P=0.001) between the two groups. There were no statistical differences between other clinical features. Conclusions Our findings strongly support a relationship between diabetes and older age, later clinical stage and T stage, higher recurrence and mortality rate, and worse prognosis in breast cancer patients.