摘要：目的 通过多中心随机对照的临床试验研究，探讨以胶原蛋白为基质的肠内营养制剂与标准型肠内营养制剂对患 者营养状况的影响，判断新型肠内营养制剂的临床应用效果。 方法 本研究共 6 家医疗单位共同参与，共收集 74 例，随机 分为对照组（标准肠内营养）及干预组（以胶原蛋白为基质的肠内营养），口服补充 1673.6kJ（400kcal） /d，持续 21 天， 检测研究开始前后患者体格指标、营养相关指标及安全性指标。 结果 组内比较显示两组患者食用肠内营养制剂后营养风险 筛查 NRS 2002 评分显著下降（P ＜ 0.025），血白蛋白较食用前显著增高（P ＜ 0.025），组间比较显示对照组与干预组体 格指标、营养相关指标及安全性指标均无统计学差异（P ＞ 0.025）。 结论 新型肠内营养制剂与标准型肠内营养制剂均可 以有效改善患者的营养状况。

Abstract: Objective The aim of this study was to understand nutritional status in hospitalized patients with collagen-based medical foods and standard enteral nutrition by muti-center clinical researches, and provide scientific reference for medical foods. Methods 6 units joint in this research. we collected 74 patients, patients were divided into two groups ( group with standard enteral nutrition and group with collagen-based medical foods) according to random number table, add 1673.6kJ(400 kcal)/d in 21 days, detect medical indicators ,laboratory examination and gastrointestinal reaction before and after the research. Results NRS2002 has significantly decreased and ALB has significantly increased after using enteral nutrition (P<0.025). Nutritional status, medical indicators, laboratory examination and gastrointestinal reaction have no difference in intervention group and control group(P>0.025). Conclusions The new type of enteral nutrition preparations and standard enteral nutrition preparations can effectively improve the nutritional status of patients.