摘要：目的 总结维生素 C 在治疗含有 KRAS、 BRAF 突变基因的结直肠癌中的研究结果，归纳分析其抗肿瘤的生理机制。 方法 以维生素 C、结直肠癌作为主题词，在 CNKI 和 PubMed 中查阅相关文献，并对结果进行归纳总结。 结果 结合肿瘤 细胞代谢特点和活性氧对肿瘤细胞的影响，发现维生素 C 可以伴随 KRAS、 BRAF 突变基因导致的糖酵解活动的升高被而 被转运到细胞内，导致细胞内不平衡的氧化还原态，使细胞供能受阻，从而饥饿肿瘤细胞，来达到抗肿瘤的作用。 结论 注 射大剂量维生素 C 可以抑制小鼠体内含 KRAS、 BRAF 突变基因的结直肠肿瘤的生长，这一发现可能指导未来临床试验。

Abstract: Objective To summarize research outcomes about vitamin C selectively kills KRAS, BRAF mutant colorectal cancer cells in cancer treatment, analysis and generalize the physiological mechanism. Methods Related articles were retrieved by searching the PubMed and CNKI database with the key words “vitamin C” and “colorectal cancer”. Results Combine the metabolic characteristics of tumor and the influence by ROS, vitamin C can be transport into cancer cells accompany with high glycolysis level resulting from KRAS, BRAF mutant cell. Due to unbalanced oxidation-reduction state in cells, cancer cells were killed by energy supply blocked. Conclusions High doses vitamin C via intravenous administration can restrain tumor growth in KRAS and BRAF mutant mice, these finding may provide a mechanistic rationale for further clinical trials.