摘要：目的 探讨联合应用 NRS 2002 和 PG-SGA 量表调查初治的晚期胃癌患者营养风险和营养不良发生率，并评估其对化疗后相关的毒副反应发生率的影响。 方法 采用连续入组的方法，筛选初治的晚期胃癌患者，应用 NRS 2002 和 PGSGA、实验室检测指标等方法评估患者的营养风险和营养不良，比较 2 种工具在调查结果上的差异，分析营养风险与传统客观指标的相关性。 结果 共 71 例患者完成营养调查。 NRS 2002 调查显示营养风险发生率为 67.61%； PG-SGA 调查营养不良发生率为 80.28%，两者存在统计学意义（P<0.05）。根据 NRS 2002 评定结果分组， BMI 在无营养风险组及有营养风险组间有统计学差异；根据 PG-SGA 评分结果分组，前白蛋白、白蛋白、 CRP 在无营养风险组及有营养风险组间存在统计学差异，存在营养风险组的患者化疗后相关毒副反应（中性粒细胞减少 I/II 和疲乏 I/II ）发生率高于无营养风险组的患者。结论 NRS 2002 和 PG-SGA 均适用于晚期胃癌患者的营养状况调查，但 PG-SGA 营养不良检出率更高，能更有效地评估患者的营养状况。对于初诊的晚期胃癌患者在化疗前推荐使用 PG-SGA 量表进行全面评估，以更好地指导临床营养治疗。

Abstract: Objective The aim of this study was to investigate the nutritional risk in patients with advanced gastric cancer received chemotherapy, using nutritional risk screening 2002 (NRS 2002) and patient-generated subjective global assessment (PGSGA), and to determine the potential relationship between the nutritional statusand the chemotherapy-related toxicity. Methods A continuous approach was used to screen patients with advanced gastric cancer, the NRS2002, PG-SGA, laboratory test indicators and other methods were applied to evaluate the nutritional risk and malnutrition of patients, the differences between the two kinds of tools in the investigation results were compared, and the correlation between nutritional risks and traditional objective indicators were analyzed. Results A total of 71 patients completed the nutrition survey. NRS survey shows that the incidence of nutritional risk was 67.61%, the incidence of malnutrition in PG-SGA was 80.28%, there was statistical significance between the two (P<0.05).When group according to the assessment results of NRS 2002, BMI was significantly different between the non-nutritional risk group and the nutritional risk group; when group by PG-SGA score results, prealbumin, albumin and CRP was significantly different between the two kinds of groups, the related incidence of adverse reactions (neutrophils reduced I/II and weary I/II) of patients with the nutritional risk group after their chemotherapy is higher than that of the patients belonging to the non-nutritional risk group. Conclusions Both NRS 2002 and PG-SGA are applicable to the nutritional status investigation of patients with advanced gastric cancer, but the malnutrition detection rate of PG-SGA was higher, so it can assess the nutritional status of patients more effectively. The PG-SGA scale is recommended to carry out the comprehensive evaluation for advanced gastric cancer patients before chemotherapy, so as to better guide clinical nutrition therapy.