摘要：目的 综述膳食纤维摄入量对预防前列腺癌发生关系及可能的作用机制，为前列腺癌的营养预防提供依据。 方法 回顾近几年来国内外发表的膳食纤维和前列腺癌发病相关的中英文文献。 结果 近期有病例对照研究的 Meta 分析结果发现膳食纤维能够降低前列腺癌的发病风险，而队列研究的 Meta 分析结果显示膳食纤维的摄入量与前列腺癌的发生风险无关。膳食纤维对前列腺癌的作用机制可能涉及改变血液中 SHBG、睾酮和雌二醇的水平，改善胰岛素的敏感性，降低胰岛素样生长因子的活性，促进前列腺癌细胞的凋亡，抑制肿瘤细胞的黏附、迁移等。 结论 膳食纤维抗前列腺癌作用的机制尚需要进一步研究，现有研究尚不能完全支持膳食纤维可以降低前列腺癌的发生风险。

Abstract: Objective To elaborate the possible relationship and mechanism between the intake of dietary fiber and prostate cancer risk, and provide evidence for the nutritional prevention of prostate cancer. Methods We review and research the domestic and foreign published literature about the relationship between dietary fiber and prostate cancer. Results The latest Meta analysis of case control study showed that dietary fiber can reduce the risk of prostate cancer, but the Meta analysis of cohort study showed that the intake of dietary fiber was not associated with the risk of prostate cancer. Effect of dietary fiber on prostate cancer may be involved in the change of SHBG, testosterone and estradiol levels, the improvement of insulin sensitivity, the decline of the activity of insulin like growth factor , the apoptosis in human prostate cancer cells and the inhibition of adhesion and migration of prostate cancer cells. Conclusions The mechanism of the effect of dietary fiber on prostate cancer needs to be further studied. The existing research can not completely support the theory that dietary fiber can reduce the risk of prostate cancer.