摘要：目的 研究灵芝孢子油口服乳的免疫增强作用。 方法??以 H22 荷瘤小鼠为研究对象，分对照组（玉米油）、阳性对照组（康莱特软胶囊）、灵芝孢子油低组、灵芝孢子油高组、灵芝孢子油口服乳低组、灵芝孢子油口服乳高组 6 组，观察灵芝孢子油口服乳对荷瘤小鼠的体液免疫功能、网状内皮系统吞噬功能、迟发型变态反应及抑瘤效果和生物调节因子的影响。 结果??灵芝孢子油口服乳 1.2g/kg 可增加 H22 荷瘤小鼠的血清 HC50 值，可明显增强 H22 荷瘤小鼠的廓清指数，可适当提高 H22 荷瘤小鼠的肝脏系数、脾脏系数、吞噬系数；对二硝基氟苯诱导的小鼠迟发型变态反应呈阳性，可显著升高H22 荷瘤小鼠血清 IL-1、 TNF-α、 IFN-γ 的含量。 结论??灵芝孢子油口服乳具有显著的增强免疫作用，可提高 H22 荷瘤小鼠的生物调节因子 IL-1、 TNF-α、 IFN-γ 的水平。

Abstract: Objective To study the effects of G. lucidum spore oil oral emulsion an enhancing the function of immune system.Methods H22 Tumor bearing mice as the research object were divided into six groups: negative control group (corn oil), positive control group (Kanglaite Soft Capsules), G. lucidum spore oil low dose group, G. lucidum spore oil high dose group, G. lucidum spore oil oral emulsion low dose group, G. lucidum spore oil oral emulsion high dose group. Observe the effect of G. lucidum spore oil oral emulsion on the function of humoral immunity, phagocytic function of reticuloendothelial system, delayed type allergic reaction and the effect of inhibiting tumor and biological regulation factors in H22 tumor bearing mice. Results G. lucidum spore oil oral emulsion 1.2g/kg could increase the serum HC50 value of H22 tumor bearing mice, could significantly enhance the clearance index of H22 tumor bearing mice, could improve the liver coefficient, spleen coefficient and phagocytic coefficient of H22 tumor bearing mice, was positive on DNFB induced delayed hypersensitivity reaction and could significantly increase the content of serum IL-1, TNF-alpha, IFN-gamma of H22 tumor bearing mice. Conclusions G. lucidum spore oil oral emulsion can enhance the immune function and improve the levels of biological regulatory factors IL-1, TNF-alpha, IFN-gamma of H22 tumor bearing mice.