摘要
摘要： 生酮饮食（ketogenic diet， KD）原本是应用于抗癫痫治疗的一种食品组合，随着社会发展及慢性代谢性疾病发病率的升高，研究者们逐渐将目光转移到 KD 与代谢性疾病研究。代谢失调是肿瘤基本生物学特征之一，其中“Warburg 效应”是肿瘤细胞代谢重编程的核心，因此，对糖代谢具有调节作用的 KD 日益受到肿瘤研究者的关注。本文阐释了 KD 抗肿瘤的机制，包括减少葡萄糖供应、降低胰岛素和胰岛素样生长因子水平、改善免疫应答抑制、调节 mTOR 途径、增加肿瘤细胞的氧化应激、抑制炎症反应和调节线粒体功能等。这些机制为 KD 在抗肿瘤领域的应用提供了理论依据。
Abstract
Abstract: Ketogenic diet was a diet combination used primarily to treat epilepsy. With the high prevalence of chronic metabolic diseases and rapid social development, researchers began to focus on the relationship between KD and metabolic syndrome.Metabolic disorder is one of the main biological characteristics of cancer, and “Warburg effect” is the core of the reprogramming of cancer metabolism, resulting in increasing attention on KD with the ability of regulating glycometabolism. This reviwew demonstrated the antineoplastic mechanism of KD, including reducing glucose supply, decreasing the insulin and IGF-1, improving the immune response inhibition, regulating the mTOR pathway, increasing oxidative stress of tumor cells, controlling inflammatory reactions and regulating the function of mitochondria, which provided theoretical basis for application of KD to the cancer treatment in the future.
关键词
生酮饮食 /
肿瘤 /
机制
Key words
Ketogenic diet /
Tumor /
Mechanism
曲芊诺;饶本强;石汉平.
生酮饮食的抗肿瘤机制[J]. 肿瘤代谢与营养电子杂志. 2016, 3(3): 191-194
QU Qian-nuo;RAO Ben-qiang;SHI Han-ping.
The mechanism of anti-tumor for ketogenic diet[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2016, 3(3): 191-194
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