摘要：骨骼肌也被称为瘦体组织，它参与人体的所有活动，与机体健康、生活能力和生活质量密切相关。瘦体组织占
人体将近一半的质量，其质量大小与蛋白质的合成和分解代谢密切相关，并且受到多种信号途径的调控。瘦体组织质量的
维持与调控受正性调节和负性调节影响，前者主要包括哺乳动物雷帕霉素靶蛋白、转化生长因子 -β、过氧化物酶体增殖物
激活受体 γ 共激活因子 -1α 和 G 蛋白等信号途径；后者主要包括生长停滞与 DNA 损伤诱导蛋白 45、核转录因子 kappa B
以及肌肉生长抑制素等信号途径。通过研究瘦体组织的这些信号调控途径，将为肌肉相关疾病的临床研究和治疗提供依据。
  

 Lean body mass, which accounts for nearly half of the mass of the human body, participates in all human activities
and is closely relates to human health, living ability and quality. The quality of lean body tissue is closely related to the synthesis,
decomposition and metabolism of protein, and the quality of lean body tissue is regulated by many signal pathways in modern
medical research. Regulating signaling pathways of lean body mass includes positive and negative regulation, of which the former
one mainly involves in mammalian target of rapamycin pathway, transforming growth factor beta pathway, peroxisome proliferating
activated receptor co-activator pathway and G protein pathway and the latter one mainly involves in growth arrest and DNA damageinducible 45 pathway, nuclear factor kappa B pathway and myostatin pathway. In a conclusion, it will provide a guidance for the
clinical research and treatment of the skeletal muscle related disease by research on the regulating signaling pathways of lean body
mass.