环境因素（如营养因素、理化因素、生活方式等）通过缓慢而长期的基因 - 环境交互作用，可能影响基因突变、
药物敏感和耐药，进而可能影响肿瘤靶向治疗的选择或治疗疗效。在放化疗过程中，肿瘤治疗前的营养状况是一个重要的
预后因素，但在靶向治疗时代，它对靶向治疗的预后提示价值常常被忽视。目前尚无学者就包含营养因素在内的环境因素
对靶向治疗的影响进行专门研究。为探讨环境因素对肿瘤靶向治疗的影响，以便为肿瘤临床分子靶向治疗提供更多的参考
依据，本文就“环境因素对肿瘤靶向治疗影响的研究进展”予以综述。
  

Through slow and long-term gene-environment interactions, environmental factors (such as nutritional factors,
physical and chemical factors, patterns of life, etc.) might cause genetic mutation and affected drug-sensitivity, thus might affect
the choice or the treatment efficacy of tumor-targeted therapy. Nutritional status before cancer treatment had been considered as an
important prognostic factor in cancer chemotherapy and radiotherapy. However, in the era of cancer molecular-targeted therapy, its
prognostic values have often been ignored. As far as we known, there was no study specifically address the roles of environmental
factors including nutritional factors on tumor-targeted therapy. To throw some light on this emerging research area and provid more
basis for molecular-targeted therapy of clinical oncology, we made an review about the research progress in the effects of nutritional
factors on tumor-targeted therapy.