目的  探讨营养治疗对头颈部肿瘤患者以铂为基础双药化疗联合放疗患者营养状况的影响。方法  选取本院治疗 的 96 例头颈部肿瘤患者，随机分为营养治疗组（研究组，n=48）和日常饮食组（对照组，n=48），治疗过程中分别给予 营养治疗和日常饮食，观察两组患者治疗期间的营养状况变化，以体重变化为主要观察指标，同时比较其他营养相关血液 学指标，应用 SPSS 19.0 软件进行相关统计分析。结果  两组患者在治疗期间均出现了不同程度的体重丢失、骨髓抑制和营 养相关指标下降。其中营养治疗组的体重丢失明显低于日常饮食组，具有统计学差异（P=0.001）；白细胞、淋巴细胞、血 红蛋白减少的发生率更低（P=0.009、P=0.000、P=0.033）；且低蛋白血症，低钙、低镁血症的发生概率和严重程度均低于 对照组（P=0.010、P=0.020、P=0.006），具有统计学差异。另外，研究组中、重度急性期反应蛋白升高的患者比例明显低 于对照组，具有统计学差异（P=0.000）。结论  营养治疗可以改善头颈部肿瘤放化疗的营养状况，体重丢失的发生率更低， 而且白细胞、淋巴细胞、血红蛋白、血浆白蛋白等血液学指标下降的发生率低，减轻了治疗相关毒副反应，但是否会带来 长期生存获益还有待进一步研究。

Objective To investigate the effects of nutritional therapy on nutritional status during the therapy of head and neck cancer patients, which were treated with platinum medication and chemoradiotherapy. Methods A total of 96 cases of head and neck cancer patients were randomly divided into a study group (n=48) and a control group (n=48). They were given nutritional intervention and conventional diet respectively during radiotherapy and chemotherapy. The nutritional status of the two groups were observed. The primary end point of this study was body weight changes, and the secondary indicators of this study included white blood cells, lymphocyte, albumin and other nutritional indicators. The statistics were analyzed by using SPSS software package. Results Both groups of patients showed different degrees of weight loss, bone marrow suppression and decreasing nutritional indicators during the treatment. The study group’s body weight loss (P=0.001), the reduction of white blood cells (P=0.009), lymphocytes (P=0.000), hemoglobin (P=0.033) and hypoproteinemia (P=0.010), the chances and severity of low calcium (P=0.020) and magnesium (P=0.006) were lower than the control group’s, these are with statistical differences. Moreover, in the study group, the proportion of the increase of the acute phase reactive protein was significantly lower than that of the control group (P=0.000). Conclusions Nutritional intervention can reduce the incidence of malnutrition in head and neck cancer during radiotherapy and chemotherapy. However whether it will lead to long-term survival benefits, further studies are needed.