目的 探讨静脉补充谷氨酰胺对结肠癌患者术后肠黏膜屏障功能的影响。方法 选取 2016 年 5 月至 2017 年 8 月在山西医科大学第一医院进行结肠癌手术治疗的 98 例患者，根据患者住院号尾数奇数与偶数差别，将其分成观察组 （Ala-Gln）46 例（添加丙氨酰谷氨酰胺注射液）和对照组 52 例（空白对照），通过观察两组患者血清中二胺氧化酶、 D- 乳酸（D-lactate）、内毒素（endotoxin）变化，探究两组患者术后肠黏膜屏障功能的变化情况。结果 手术前及术后第 1 天两组患者的血清中 D- 乳酸、二胺氧化酶和内毒素水平无统计学意义（P ＞ 0.05），术后第 3 天、第 5 天、第 7 天观察 组的血清中 D- 乳酸、二胺氧化酶和内毒素水平均显著低于对照组（P ＜ 0.05），术后第 3、5、7 天的 D- 乳酸、二胺氧化 酶和内毒素水平与术后第 1 天的差值均具有统计学意义，且观察组的差值显著高于对照组的差值（P ＜ 0.05）。结论 手术 能够引起结肠癌患者肠黏膜屏障功能进一步的损伤，术后静脉补充谷氨酰胺能显著改善肠黏膜屏障功能，对结肠癌患者术 后肠黏膜屏障功能恢复是有益的。

Objective To investigate the effect of intravenous glutamine (Gln) on intestinal mucosal barrier function in colon patients undergone surgery. Methods According to the number of patient hospital mantissa odd and even difference, a total of 98 patients undergoing colon cancer surgery in the First Hospital of Shanxi Medical University from May 2016 to August 2017 were selected and divided into treatment group (Ala-Gln) 46 cases (added alanyl glutamine injection) and control group of 52 patients (blank control) by observing the two groups of patients's serum levels of diamine oxidase (DAO), D-lactate (D-lactate), endotoxin Changes,in order to explore the two groups of patients with intestinal mucosal barrier function changes. Results The levels of D-lactic acid, DAO and endotoxin in the two groups before surgery and on the first day after operation were not statistically significant (P>0.05). On the 3rd, 5th and 7th day after operation in the treatment group, Serum D-lactate, DAO and endotoxin levels were significantly lower than the control group (P<0.05). The differences of D-lactate, DAO and endotoxin levels on day 3, 5, and 7 after operation with those on the first postoperative day were statistically significant, and the difference between the treatment group was significantly higher than that of the control group (P<0.05). Conclusions Surgery can cause further damage of intestinal mucosal barrier function in patients with colon cancer. Postoperative intravenous glutamine can significantly improve the intestinal mucosal barrier function, which is beneficial to the recovery of postoperative intestinal mucosal barrier function in patients with colon cancer.