摘要
目的 观察晚期非小细胞肺癌患者行紫杉醇联合顺铂方案化疗后使用脂肪乳(10%)/ 氨基酸(15)/ 葡萄糖(20%)
注射液的临床疗效。方法 采用回顾性分析方法,选取 2016 年 10 月至 2017 年 10 月的 58 例晚期非小细胞肺癌患者行紫杉
醇联合顺铂方案化疗患者,按化疗后营养补给方式分组,对照组 30 例化疗后常规多瓶输注,观察组 28 例化疗后加以脂肪
乳(10%)/ 氨基酸(15)/ 葡萄糖(20%)注射液输注。比较两组患者化疗前后的人体测量指标、营养指标、免疫功能和
生活质量。结果 两组患者化疗前的一般资料、人体测量指标、营养指标、免疫指标、生活质量评分比较,差异均无统计学
意义(P > 0.05);观察组化疗后的人体测量指标(BMI、TSF、MAMC)和营养相关血液学指标(HB、TP、PA、ALB)
数值高于对照组,差异有统计学意义(P < 0.05);观察组化疗后的免疫指标(IgM、IgG、IgA、CD4+
、CD4+
/CD8+
)数
值高于对照组,差异有统计学意义(P < 0.05);观察组化疗后在认知功能、社会功能和总体健康状态的评分显著高于对
照组,差异具有统计学意义(P < 0.05),观察组在恶心呕吐的症状领域得分低于对照组,差异具有统计学意义(P < 0.05)。
结论 晚期非小细胞肺癌患者化疗后联合脂肪乳(10%)/ 氨基酸(15)/ 葡萄糖(20%)注射液进行肠外营养支持治疗,有
利于改善患者营养状况和增强患者的免疫力,同时提高患者生活质量,值得临床进一步应用。
Abstract
Objective To observe the clinical efficacy of lipid emulsion (10%)/amino acids (15) and glucose (20%) injection for patients with advanced non-small cell lung cancer after TP chemotherapy regimen. Methods The retrospective analysis was conducted in 58 patients with advanced non-small cell lung cancer who received TP chemotherapy regimen from October 2016 to October 2017. The patients were divided into two groups according to the nutritional supply methods after chemotherapy, 30 patients who received conventional multiple bottle infusions after chemotherapy were distributed into the control group, and 28 patients who received lipid emulsion (10%)/amino acids (15) and glucose (20%) injection after chemotherapy were distributed into the research group. The general information, anthropometric parameters, nutritional status, immune function, quality of life score between the two groups were compared before and after chemotherapy. Results Before chemotherapy, there were no significant differences (P>0.05) between the two groups in general information, anthropometry parameters, nutritional status and immune function. The values of anthropometric parameters (BMI, TSF, MAMC) and nutritional haemal parameters (HB, TP, PA, ALB) of the research group after chemotherapy were higher than those of the control group, and the differences were statistically significant (P<0.05); the values of immune function parameters (IgM, IgG, IgA, CD4+, CD4+/CD8+) of the research group after chemotherapy were higher than those of the control group, and the differences were statistically significant (P<0.05); the quality of life score in the fields of cognition function, social function and total health state were higher than those in the control group, and the differences were statistically significant (P<0.05); the scores in the symptom field of nausea and vomiting were lower than those in the control group, and the
differences were statistically significant (P<0.05). Conclusions The parenteral nutrition support treatment using lipid emulsion (10%)/
amino acids (15) and glucose (20%) injection for patients with advanced non-small cell lung cancer after chemotherapy is beneficial to improve the nutritional status, enhance the immunity function, improve the quality of life, so it is worthy of further clinical application.
关键词
非小细胞肺癌 /
肠外营养 /
免疫功能 /
生活质量
Key words
Non-small cell lung cancer /
Parenteral nutrition /
Immune function /
Quality of life
刘静,胡小刚,王思雄.
肠外营养治疗对晚期非小细胞肺癌患者化疗后的临床疗效[J]. 肿瘤代谢与营养电子杂志. 2018, 5(1): 78-83
LIU Jing, HU Xiao-gang, WANG Si-xiong,.
Clinical effect of parenteral nutrition on patients with advanced non-small cell lung cancer after chemotherapy[J]. Electronic Journal of Metabolism and Nutrition of Cancer. 2018, 5(1): 78-83
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}