目的 探讨晚期肿瘤患者的睡眠质量情况及其相关影响因素。方法 采用自制量表调查患者一般情况、营养状 况、运动状况及治疗情况，采用匹兹堡睡眠质量指数（PSQI）调查患者睡眠质量，评价患者睡眠质量总分及各分项得分情况 采用 t检验，睡眠质量异常发病率分析采用秩和检验，对影响睡眠质量的多因素分析采用有序 Logistic回归分析及相关分析。 结果 晚期肿瘤患者睡眠质量 7个成分评分及 PSQI总分均显著高于国内健康人群睡眠质量常模（P<0.001）。PSQI在应用于 晚期肿瘤住院患者的内部一致性高，Cronbach α系数为 0.854。61% 的晚期肿瘤患者睡眠质量异常，体质指数（BMI）降低（P= 0.010）、伴有严重癌痛（P<0.001）、PS 评分 3分（P<0.001）、只能接受对症治疗（P<0.001）、健身频率低（P=0.001）、每天健身时 间<30 min（P=0.010）的患者睡眠障碍发生率显著高于其他患者。Logistic 回归分析结果显示，疼痛（P<0.001）为睡眠质量异 常的危险因素。结论 晚期肿瘤住院患者的睡眠质量异常发生率较高，睡眠质量较差。影响晚期肿瘤患者的睡眠质量的因 素主要与病情相关，应针对这些特点制定改善晚期肿瘤患者睡眠质量的个体化方案，以提高晚期肿瘤患者生活质量。

Objective To investigate the sleep quality of patients with advanced cancer and its related influencing factors. Methods The self⁃made scale was used to investigate the general situation, nutritional status, exercise status and treatment of the patients. The Pittsburgh sleep quality index（PSQI）was used to investigate the sleep quality of the patients. The total score of sleep quality and the scores of each item were evaluated by t test. The abnormal incidence rate of sleep quality was analyzed by rank sum test. The multiple factors analysis of sleep quality was analyzed by ordinal Logistic regression and correlation analysis.. Cronbach α coefficient was used to estimate the internal consistency, and Spearman Brown formula was used to estimate the reliability. Results The scores of seven sleep quality components and the total score of PSQI of patients with advanced cancer were significantly higher than those of the normal sleep quality of healthy people in China (P<0.001). The internal consistency of PSQI scale applied to hospitalized patients with advanced cancer was high, with Cronbach α coefficient of 0.854. 61% of patients with advanced cancer had abnormal sleep quality. The incidence of sleep disorders in patients with decreased body mass index (BMI) (P=0.010), severe cancer pain (P<0.001), PS score 3 group (P<0.001), only symptomatic treatment (P<0.001), low fitness frequency (P<0.001) and less than 30 minutes of daily fitness (P=0.010) was significantly higher than that in other patients. Logistic regression analysis showed that pain (P<0.001) was a significant risk factor for abnormal sleep quality. Conclusions The incidence of abnormal sleep quality in hospitalized patients with advanced cancer is high, but the sleep quality is poor. The factors that affect the sleep quality of patients with advanced cancer are mainly related to the patient′s condition. According to these characteristics, individualized programs should be developed to improve the sleep quality of patients with advanced cancer, so as to improve the quality of life of patients with advanced cancer.