维生素D为脂溶性维生素，具有刺激肠道钙和磷酸盐的吸收，肾钙和磷酸盐的再吸收和调节骨矿物质的代谢作用。维 生素D缺乏易引起佝偻病、骨软化症、骨质疏松症及手足抽搐症；过量摄入维生素D可引起维生素D中毒。维生素D主要来源于 皮肤合成和食物。经常晒太阳是获得充足有效的维生素D的最好来源。维生素D与多种恶性肿瘤的发生、发展有关，主要集中 在两点：①观察不同人群机体维生素D水平与恶性肿瘤发病的关系；②补充维生素D对改变恶性肿瘤的发生率的影响。本文就 维生素D和多种恶性肿瘤如结直肠癌、皮肤癌等之间的相关研究展开综述发现，目前缺乏充分的证据支持，机体较高维生素D水 平，可降低恶性肿瘤的发病风险。由于目前关于维生素D与肿瘤发生、发展研究较少, 并且研究结果容易受到气候、地理环境、饮 食等因素的影响，需要进一步大样本的前瞻性研究，明确维生素D与肿瘤的关系。

Vitamin D is fat⁃soluble vitamin, which can stimulate the absorption of intestinal calcium and phosphate, absorb renal calcium and phosphate, and regulate the metabolism of bone minerals.Vitamin D deficiency easily leads to rickets, steomalacia, osteoporosis, and hand and foot spasm; excessive intake of vitamin D can cause vitamin D poisoning. It mainly comes from skin synthesis and food. Frequent sun exposure is the best source for obtaining adequate and effective vitamin D. Adults are often exposed to sunlight, generally do not develop vitamin D deficiency disease. In recent years, it has shown that vitamin D is related to the development of multiple malignant tumors. It is mainly focused on two points, one is to observe the relationship between vitamin D levels in different groups and malignant tumors, and the other is whether artificial vitamin D supplementation will change the incidence of malignant tumors. This paper reviews the relevant studies between vitamin D and various malignant tumors such as colorectal cancer and skin cancer, and the results found that there is a lack of sufficient evidence to support the body′s higher vitamin D levels, which can reduce the risk of malignant tumors. Since there are few studies on vitamin D and tumor development and development, and the results are vulnerable to climate, geographical environment, dietary factors, further prospective studies of large samples may be needed to further clarify the relationship between vitamin D and tumor.