肿瘤是全球主要的死亡原因之一，其发病率正在逐年上升。糖脂代谢异常可导致多种恶性肿瘤的发病率及死亡率 增加，如乳腺癌、肝癌、胰腺癌、结直肠癌等。糖脂代谢异常导致肿瘤进展的多种机制，包括影响细胞代谢、引起机体炎症与免 疫失调、抑制肿瘤细胞凋亡以及促进肿瘤细胞增殖和转移等，然而尚不清楚导致恶性肿瘤发生、发展的主要原因。此外，糖脂 代谢异常与恶性肿瘤的相互作用限制药物的选择、增加恶性肿瘤化学耐药性、影响手术疗效和患者预后，使恶性肿瘤治疗方案 的制定更具挑战性。二甲双胍与他汀类药物可降低多种肿瘤的风险，但相关的临床前瞻性试验尚无定论。因此，本文对糖脂 代谢紊乱与恶性肿瘤相关的研究进展进行阐述，旨在探讨糖脂代谢异常与恶性肿瘤发生的相关性，以及促进恶性肿瘤生长与 进展的潜在病理生理机制，最后将讨论降糖、降脂策略在治疗恶性肿瘤中的潜在作用。

Cancer is the leading cause of deaths worldwide and its incidence is increasing. Glucose/lipid metabolism disorders increase the incidence and mortality of many malignant tumors, such as breast cancer, liver cancer, pancreatic cancer, colorectal cancer, etc. Multiple mechanisms linking glucose/lipid metabolism and cancer progression have been described. The possible mechanisms include affecting the cell metabolism, body inflammation and immune disorders, inhibiting tumor cell apoptosis, and promoting tumor cell proliferation and metastasis. However, it remains unclear which factors are the main drivers of cancer development. The interaction between glucose/lipid metabolism disorders and cancers restricts the choice of drugs, affects the efficacy of surgery and patient prognosis, making the formulation of treatment plans more challenging. Metformin and statins may reduce the risk of a variety of cancers, but the results of relevant clinical prospective trials are still unclear. Therefore, it is necessary to analyze the research progress related to glucose/lipid metabolism disorders and cancers. This review aims to explore the association between glucose/lipid metabolism disorders and the occurrence of cancers. Discuss the evidence supporting glucose/lipid metabolism disorders in cancers and how this phenotype may contribute to cancers growth and progression. Finally, the potential role of blood glucose or lipid lowering strategies for the treatment of cancers will be discussed.