目的 探讨肠内营养对晚期肺癌合并肺炎患者炎症因子、癌性疲乏和生活质量的影响。方法 选取北京市朝阳区桓兴肿 瘤医院2019年5月至2020年3月收治的124例晚期肺癌合并肺炎患者作为研究对象，按照抽签法将患者分为观察组和对照组。 其中对照组患者进食普通食物，观察组在此基础上加用肠内营养治疗，观察两组患者炎症因子、癌性疲乏和生活质量状况。结果 治疗前两组患者降钙素原、C 反应蛋白、白介素⁃6、肿瘤坏死因子 α 及 α⁃1 酸性糖蛋白差异无统计学意义（t=0.161、0.134、 0.692、⁃0.412、0.226，P=0.436、0.446、0.245、0.340、0.410），治疗2周后观察组、白介素⁃6、肿瘤坏死因子α及α⁃1酸性糖蛋白水平均 显著优于对照组（t=3.566、9.833、3.951，P<0.01）。治疗后观察组患者疲乏总分为（22.07±3.45）分，明显低于对照组（31.12±3.13） 分；治疗后观察组躯体疲乏方面评分（9.93±4.31）分、情感疲乏方面评分（6.11±2.36）分、认知疲乏（6.03±3.22）分与对照组躯体疲乏 方面评分（12.25±3.77）分、情感疲乏方面评分（9.84±2.79）分、认知疲乏（9.03±1.98）分相比差异均有统计学意义（P<0.01）。治疗前 观察组生活质量评分与对照组相比差异无统计学意义（P>0.05）。观察组患者治疗后生活质量总分为（191.22±5.39）分，明显高于 对照组（150.88±6.27）分；观察组躯体功能方面评分为（48.17±10.62）分、心理功能方面评分为（58.24±2.39）分、社会功能评分为 （46.55±2.16）分、物质生活评分为（38.36±4.88）分与对照组躯体功能方面评分为（40.95±12.31）分、心理功能方面评分为（41.45± 1.77）分、社会功能评分为（37.24±3.79）分、物质生活评分为（31.24±5.13）分比较，差异有统计学意义（P<0.05）。结论 对晚期肺癌 合并肺炎患者的治疗中采用肠内营养制剂可有效提高肺部感染的治疗效果，明显减轻癌性疲乏并提高生活质量。

Objective To investigate the effects of enteral nutrition on inflammatory factors, cancer⁃induced fatigue and quality of life in patients with advanced lung cancer complicated with pneumonia. Methods A total of 124 patients with advanced lung cancer complicated with pneumonia admitted to Cancer Hospital of Huanxing Chaoyang District Beijing from May 2019 to March 2020 were selected as the research object, and the patients were divided into observation group and control group on average according to the lottery method.The control group was fed ordinary food, and the observation group was supplemented with enteral nutritional support. Inflammatory factors, cancer⁃induced fatigue and quality of life were observed in 2 groups. Results There were no significant differences in procalcitonin, C⁃reactive protein, interleukin⁃6, tumor necrosis factor ⁃α and α⁃1 acidic glycoprotein between 2 groups before treatment (t=0.161, 0.134, 0.692, ⁃0.412, 0.226, P=0.436, 0.446, 0.245, 0.340, 0.410). After 2 weeks of treatment, the levels of interleukin⁃6, tumor necrosis factor ⁃α and α⁃1 acid glycoprotein in the observation group were significantly higher than those in the control group (t =3.566, 9.833, 3.951, P < 0.01).After treatment, the fatigue score in the observation group was (22.07±3.45) points, significantly lower than that in the control group (31.12±3.13) points; after treatment, the scores of physical fatigue (9.93±4.31), emotional fatigue (6.11±2.36), cognitive fatigue (6.03±3.22) and the scores of physical fatigue (12.25±3.77), emotional fatigue (9.84±2.79) and cognitive fatigue (9.03±1.98) in the observation group were compared with those in the control group points were statistically significant (P < 0.01).Before treatment, there was no significant difference in quality of life score between the observation group and the control group (P > 0.05). The total score of quality of life in observation group was (191.22±5.39) points, which was significantly higher than that in control group (150.88±6.27) points. The scores of the observation group were (48.17±10.62), mental function (58.24±2.39), social function (46.55±2.16), material life (38.36±4.88) and the control group were (40.95±12.31). The scores of psychological function, social function and material life were (41.45±1.77) points, (37.24±3.79) points and (31.24±5.13) points respectively (P < 0.05). Conclusion In the treatment of patients with advanced lung cancer complicated with pneumonia, enteral nutrition agents can effectively improve the therapeutic effect of lung infection, significantly reduce fatigue caused by cancer and improve the quality of life, which has important clinical significance.