胰腺癌是一种致死率较高的恶性肿瘤，具有转移早、诊断晚、治疗耐药等特征，且手术根治率低，预后较差，目前针对 胰腺癌的一线联合化疗方案整体治疗效果不佳，治疗后患者生存率仍较低，亟需开发有效的干预治疗策略。维生素D对多种恶 性肿瘤的发生和发展具有积极的预防和治疗作用，近年来，维生素D防治胰腺癌已成为研究热点之一。维生素D及其衍生物对 治疗胰腺癌具有积极作用，能够改善预后，降低胰腺癌的死亡率。但由于当前研究较少，缺乏充分的证据支持，今后仍需高质量 临床研究探讨维生素D的补充剂量、干预时间及联合用药等，为治疗及预防胰腺癌提供充足的证据。本文就维生素D对胰腺癌 患病率及死亡风险的影响进行了综述，探讨了维生素D治疗胰腺癌可能存在的机制，概述了维生素D及其类似物联合化疗/免疫 治疗干预胰腺癌的最新研究进展。维生素D及其衍生物是一种具有成本效益的药物，在胰腺癌的治疗研究中具有重要的价值和 广阔的应用前景。

Pancreatic cancer is a malignant tumor with high mortality, characterized by early metastasis, late diagnosis, and therapeutic resistance, the radical resection rate is low and the prognosis is poor. At present, the first⁃line combined chemotherapy regimen for pancreatic cancer is unsatisfactory, and the survival rates remain low, there is no cure or effective treatment for pancreatic cancer. Therefore, it is urgent to develop effective intervention strategies. Studies have shown that vitamin D has a positive preventive and therapeutic effect on the occurrence and development of various malignant tumors, vitamin D as a new target for prevention and treatment of pancreatic cancer, has become one of the research hotspots in recent years. At present, the results show that vitamin D and its analogues play positive roles in the treatment of pancreatic cancer, which can improve the prognosis and reduce the mortality. To data, there is no sufficient evidence to support, high quality clinical studies are needed to explore vitamin D supplementation, intervention time and combination therapy, providing sufficient evidence for the treatment and prevention of pancreatic cancer. In this article, we reviewed the effects of vitamin D on the incidence and mortality of pancreatic cancer, while discussed the possible mechanisms. The latest research progress of vitamin D and its analogues combined with chemotherapy/immunotherapy for pancreatic cancer were summarized. Taken together, vitamin D and its analogues are cost⁃effective drugs, which have important value and broad application prospects for the prevention and treatment of pancreatic cancer.