肿瘤营养学是应用营养学的方法和理论进行肿瘤预防和治疗的一门新学科，恶性肿瘤患者是微量营养素异常的高 危人群，微量营养素异常会影响肿瘤患者的治疗、预后及生存时间等。因此，对于肿瘤患者入院时需要对其进行肿瘤与营养的 双诊断。质谱作为一种高灵敏、高特异性的检测手段，可以对人体的多种指标实现精准监测，从营养学角度为肿瘤患者提供准 确、丰富的诊疗信息。本文对质谱技术在肿瘤营养诊疗中的应用进行综述，通过总结液相色谱‐三重四极杆质谱、飞行时间质 谱、电感耦合等离子体质谱等技术在肿瘤营养诊断和治疗中的应用，对人体内维生素、微量元素、糖皮质激素、治疗性药物等指 标进行精准检测，为临床肿瘤患者营养支持提供更为准确的数据支撑。

Tumor nutrition is a new discipline that applies nutrition methods and theories to prevent and treat tumors. Malignant tumor patients are at high risk of malnutrition. Malnutrition will affect the treatment, prognosis and survival time of tumor patients. Therefore, a dual diagnosis of tumor and nutrition is required for tumor patients when they are admitted to hospital. As a highly sensitive and highly specific detection method, mass spectrometry can be used for accurate monitoring of various indicators in the human body, and provide accurate and rich diagnosis and treatment information for tumor patients from the perspective of nutrition. In this paper, the application of mass spectrometry technology in tumor nutrition diagnosis and treatment was reviewed. The applications of liquid chromatography⁃triple quadrupole mass spectrometry, time⁃of⁃flight mass spectrometry, and inductively coupled plasma mass spectrometry in tumor nutrition diagnosis and treatment were summarized. This paper reviewed the accurate detection of vitamins, trace elements, glucocorticoids, therapeutic drugs and other indicators in the human body by mass spectrometry. More accurate data support will be provided to nutritional support for clinical tumor patients.