目的探究膳食供能的个体化营养对甲状腺癌术后放疗患者的影响。方法选取2018年1月至2020年6月秦皇岛市第一 医院收治的98例甲状腺癌术后放疗患者作为研究对象，根据入院建档顺序分为对照组和观察组，各49例，自放疗起给予对照组常规 营养干预，给予观察组膳食供能的个体化营养，连续干预4周。比较两组患者体重、上臂肌围及皮褶厚度、放疗耐受性、干预前后营养 状况[血清白蛋白（SA）、前白蛋白（PA）、转铁蛋白（TF）]、癌因性疲乏、生存质量（FLIC）及营养膳食依从性。结果干预后观察组体重、 上臂肌围及皮褶厚度均高于对照组（P<0.05）；干预后观察组PA（350.47±52.32）mg/L、SA（35.48±2.01）g/L、TF（2.26±0.54）g/L高于对 照组（321.48±42.32）mg/L、（31.12±2.86）g/L、（1.90±0.50）g/L（P<0.05）；观察组放疗耐受性高于对照组（P<0.05）；观察组癌因性疲乏程 度（无疲乏或轻度疲乏48.98%、中等疲乏30.61%、重度疲乏20.41%）低于对照组（26.53%、36.73%、36.73%）（P<0.05）；干预后观察组 FLIC评分高于对照组（P<0.05）；观察组营养膳食依从性高于对照组（P<0.05）。结论膳食供能的个体化营养有助于改善甲状腺癌术 后放疗患者营养状况，维持体重，并可减轻癌因性疲乏，增强放疗耐受性，改善生存质量水平。

Objective To explore the effect of individualized nutritional intervention based on dietary energy on the radiotherapy tolerance, nutritional status and quality of life of patients with postoperative radiotherapy for thyroid cancer. Method 98 patients with postoperative radiotherapy for thyroid cancer treated in Qinhuangdao First Hospital from January 2018 to June 2020 were selected as the research objects. According to the filing order of admission, patients were divided into control group and observation group, 49 patients each. From radiotherapy, the control group was given routine nutrition intervention, and the observation group was given individualized nutrition intervention based on dietary energy supply for 4 weeks. The body mass, upper arm muscle circumference and skinfold thickness, radiation tolerance, nutritional status [serum albumin (SA), prealbumin (PA), transferrin (TF)] before and after intervention, cancer⁃related fatigue, quality of life (FLIC) and nutritional diet compliance were compared between the two groups. Result After the intervention, the body weight, upper arm muscle circumference and skinfold thickness of the observation group were higher than those of the control group (P<0.05); after the intervention, the observation group had PA (350.47±52.32) mg/L, SA (35.48±2.01) g/L, TF (2.26±0.54) g/L are higher than the control group (321.48±42.32) mg/L, (31.12±2.86) g/L, (1.90±0.50) g/L (P<0.05); the radiotherapy tolerance of the observation group was higher than that of the control group (P<0.05); the degree of cancer⁃related fatigue in the observation group (no fatigue or mild fatigue 48.98%, moderate fatigue 30.61%, severe fatigue 20.41%) was low In the control group (26.53%, 36.73%, 36.73%) (P<0.05); the FLIC score of the observation group after intervention was higher than that of the control group (P<0.05); the nutrition diet compliance of the observation group was higher than that of the control group (P<0.05). Conclusion Individualized nutritional intervention based on dietary energy can help improve the nutritional status of patients undergoing radiotherapy for thyroid cancer, maintain their body mass, reduce cancer⁃related fatigue, enhance radiotherapy tolerance, and improve the quality of life.