目的探讨口服营养补充制剂中添加β‐羟基‐β‐甲基丁酸（HMB）对Ⅰ～Ⅲ期老年结肠癌患者术后疲劳状态及生活质量 的改善作用。方法选取2020年1月至2021年6月于首都医科大学附属北京世纪坛医院、昆明医科大学第一附属医院、哈尔滨医 科大学附属第四医院和同济大学附属第十人民医院住院行结肠癌根治术的老年患者，分为HMB干预组和对照组。采用疲劳评 分简表（BFI）和生命质量测定量表（QLQ‐C30）评估患者术前、术后疲劳程度和生活质量；计时起走测试评估患者综合体能；白细 胞计数和C反应蛋白评估患者炎症水平变化。记录患者总住院时间和住院总费用。结果HMB干预组患者术后疲劳程度在各 维度评分均优于对照组患者（均P<0.05）。HMB干预组患者术后总体生活质量优于对照组［（41.2±2.6）分比（45.7±3.1）分，P=0.001］。 其中，在生活质量症状领域，HMB干预组患者得分情况优于对照组［（9.1±7.9）分比（15.2±8.2）分，P=0.008］。HMB干预组患者术 后白细胞计数水平低于对照组患者（[ 5.5±1.6）×109/L比（6.6±1.7）×109/L，P=0.042]。结论相较于常规口服营养补充，添加HMB的 口服营养补充可以更好地改善老年结肠癌患者术后总体生活质量和疲劳程度，降低患者总体炎症水平。

Objective To study the effects of adding β⁃hydroxy⁃β⁃methylbutyrate (HMB) to oral nutritional supplements on elderly patients with stage Ⅰ-Ⅲ colon cancer to improve postoperative fatigue and quality of life. Method Colon cancer patients enrolled from January 2020 to June 2021 in Beijing Shijitan Hospital, First Affiliated Hospital of Kunming Medical University, Fourth Affiliated Hospital of Harbin Medical University, and Tenth People's Hospital Affiliated to Tongji University were hospitalized for radical resection. Divided into HMB intervention group and control group, by using the brief fatigue inventory (BFI) and the quality of life questionnaire⁃core 30 (QLQ⁃C30) scale to assess the degree of fatigue and quality of life of patients before and after surgery. Timed take⁃off test was used to assess the patient's overall physical fitness, white blood cell count and C⁃reactive protein to assess the changes in the patient's inflammation level. The patient's total hospital stay and total hospital expenses were recorded. Result The postoperative fatigue of the HMB intervention group was better than that of the control group in all dimensions (P<0.05). The overall quality of life of patients in the HMB intervention group was better than that in the control group [(41.2±2.6) vs (45.7±3.1), P=0.001]. Among them, in the field of quality of life symptoms, the scores of patients in the HMB intervention group were better than those in the control group[ (9.1±7.9) vs (15.2±8.2), P=0.008]. The postoperative white blood cell count of the HMB intervention group was lower than the control group [(5.5±1.6)×109/L vs (6.6±1.7)×109/L, P=0.042]. Conclusion Compared with regular oral nutritional supplements, oral nutritional supplements with HMB can improve the overall quality of life and fatigue better, and reduce the overall inflammation level of elderly patients with colon cancer after surgery.