目的 探讨益生菌联合益生元对宫颈癌患者放射性肠炎发生率的影响。 方法 回顾性纳入 2019 年 11 月至 2021 年 11 月在重庆大学附属三峡医院肿瘤科初次接受放疗的宫颈癌患者 82 例,根据营养方式不同分为对照组、观察组各 41 例。 对 照组采用常规治疗与基础护理,观察组在对照组基础上加用益生菌和益生元。 两组患者年龄、病理类型、宫颈癌分期等无差 异(均 P>0. 05)。 放疗前和放疗结束后 7 d,对比炎症因子:白介素-1(IL-1)、白介素-6(IL-6)、肿瘤坏死因子 α(TNF-α);肠 鸣音次数;免疫球蛋白水平:免疫球蛋白 G(IgG)、免疫球蛋白 A(IgA)、免疫球蛋白 M(IgM);比较放疗结束后 7 d 两组放射性 肠炎发生率、重度放射性肠炎发生率。 结果 放疗前 7 d,两组炎症因子、免疫球蛋白水平,以及肠鸣音次数无差异;放疗结束 后 7 d,观察组炎症因子(IL-1、IL-6、TNF-α)水平低于对照组,观察组肠鸣音次数低于对照组,观察组 IgG、IgA、IgM 水平高于 对照组,两组差异均有统计学意义(均 P<0. 05)。 放疗结束后 7 d,观察组放射性肠炎发生率、重度放射性肠炎发生率低于对 照组,差异均有统计学意义(P<0. 05)。 结论 益生菌联合益生元可预防宫颈癌患者放射性肠炎的发生。

Objective To explore the effect of probiotics combined with prebiotics in reducing the incidence of radiation enteritis in patients with cervical cancer. Method From November 2019 to November 2021 82 patients with cervical cancer who received radiotherapy for the first time from Three Gorges Hospital Affiliated to Chongqing University were randomly divided into control group and observation group depending on the way of nutrition. The control group was treated with routine treatment and basic nursing and the observation group was treated with probiotics and prebiotics on the basis of the control group. There was no difference in age pathological type and cervical cancer stage between the two groups all P > 0. 05 . Before and 7 days after radiotherapy compare the inflammatory factors interleukin-1 IL-1 interleukin-6 IL-6 tumor necrosis factor-α TNF-α number of bowel sounds immunoglobulin level immunoglobulin G IgG immunoglobulin A IgA immunoglobulin M IgM the incidence of radiation enteritis and the incidence of severe radiation enteritis were compared between the two groups one week after radiotherapy. Result Before radiotherapy there was no significant difference in the levels of inflammatory factors immunoglobulin and the number of bowel sounds between the two groups all P > 0. 05 7 days after radiotherapy the levels of inflammatory factors IL-1 IL-6 TNF-α in the observation group and the number of bowel sounds in the observation group were lower than those in the control group and the levels of IgG IgA and IgM in the observation group were higher than those in the control group. The difference between the two groups was statistically significant all P < 0. 05 . 7 days after radiotherapy the incidence of radiation enteritis and severe radiation enteritis in the observation group were lower than those in the control group P < 0. 05 . Conclusion Probiotics combined with prebiotics can reduce the incidence of radiation enteritis in patients with cervical cancer.