目的 探讨血清肉碱水平与结直肠癌放疗患者肌肉减少及营养状态的相关性。 方法 选取 2020 年 1 月至 2021 年 12 月河北省邯郸市中心医院收治的结直肠癌放疗患者 84 例作为病例组,其中血清肉碱水平≥39. 77 μmol / L(高水平组) 42 例,血清肉碱水平<39. 77 μmol / L(低水平组)42 例,同时选取同期健康体检者 61 例作为对照组。 采用酶循环法测定血清游离 肉碱水平,对病例组和对照组血清游离肉碱水平进行分析。 分析病例组两组营养状态、肌肉状态;采用 Pearson 相关分析血清 肉碱水平与结直肠癌放疗患者肌肉减少及营养状态的相关性。 结果 病例组血清游离肉碱水平显著低于对照组(P<0. 05);病 例组中两组血清肉碱水平、行走速度、手握力、前白蛋白、股骨颈骨密度(BMD)、血红蛋白(Hb)、白蛋白(ALB)、总蛋白(TP)、 骨骼肌指数(SMI)、瘦体组织指数(LTI)对比差异均具有统计学意义(P<0. 05);Pearson 相关性分析显示,血清肉碱水平与 SMI (r = 0. 676)、股骨颈 BMD(r = 0. 544)、行走速度( r = 0. 560)、手握力( r = 0. 609)、LTI( r = 0. 411)、TP( r = 0. 532)、前白蛋白( r = 0. 532)、ALB(r = 0. 623)、Hb(r = 0. 376)呈正相关(P<0. 05)。 结论 结直肠癌放疗患者血清肉碱水平呈高表达,其可作为结直肠癌放疗患者肌肉减少及营养状况的血清标志物。

Objective To investigate the correlation between serum carnitine levels and sarcopenia and nutritional status in colorectal cancer patients undergoing radiotherapy. Method A total of 84 patients with colorectal cancer radiotherapy who were treated in our hospital from January 2020 to December 2021 were selected as the case group including 42 cases with serum carnitine level ≥39. 77 μmol/ L high level group and serum carnitine level was lower than 39. 77 μmol / L are 42 cases low level group . and 61 cases of healthy subjects during the same period were selected as the control group. Serum free carnitine levels were determined by enzyme cycle method and serum free carnitine levels in the case group and control group were analyzed. The nutritional status and muscle status of the two groups in the case group were analyzed Pearson correlation was used to analyze the correlation between serum carnitine levels and sarcopenia and nutritional status in colorectal cancer radiotherapy patients. Result The serum free carnitine level in the case group was significantly lower than that in the control group P<0. 05 . In the case group the serum carnitine levels walking speed hand grip strength prealbumin femoral neck BMD hemoglobin Hb albumin ALB total protein TP skeletal muscle index SMI and lean body tissue index LTI were significantly different P<0. 05 Pearson correlation analysis showed that serum carnitine levels were significantly associated with SMI r = 0. 676 femoral neck BMD r = 0. 544 walking speed r = 0. 560 hand grip strength r = 0. 609 LTI r = 0. 411 TP r = 0. 532 prealbumin r = 0. 532 ALB r = 0. 623 and Hb r = 0. 376 were positively correlated P<0. 05 . Conclusion The serum carnitine level is highly expressed in patients with colorectal cancer radiotherapy which can be used as a serum marker for sarcopenia and nutritional status in patients with colorectal cancer radiotherapy.