目的 掌握维生素和抑郁研究的现况。 方法 对 WoS 数据库精准检索(主题词和自由词结合),得到“维生素”和 “抑郁”研究的文献集群。 使用数据库在线分析工具、NoteExpress 软件分析模块进行一般定量分析,使用 CiteSpace 软件进行 网络聚类共现分析。 阅读高质量文献,结合定量分析结果进行系统评价。 结果 检索得到 2817 个结果,这些文献主要发表在 营养学和精神病学相关杂志上,有 3 个增长较为显著的年份,美欧等国的文献占绝大多数。 前 20 篇高被引文献中 9 篇来自美 国(45%),但高产作者、高频引文来自澳大利亚,以及欧洲国家。 维生素 D、氧化应激、维生素 B12 、叶酸、维生素 E、维生素 A、 meta 分析等关键词备受关注,研究前沿包括生化标志物、肠菌、5-羟色胺、系统分析等。 最高被引文献(7 / 20),前沿引文(9 / 14),最高强度引文(13 / 20),长时长突现引文(18 / 22)中绝大多数为维生素 D 与精神健康(抑郁)的专题。 关键词时间域 2012 年迸现过一波次高频词,包括“应激”“炎症”“血 25(OH)D3 ”“补充维生素 D”“C 反应蛋白”。 引文时间域呈 3 个波次,最后一 个密集,引文聚类时间线显示不同聚类有明显时间变化趋势。 结论 维生素和抑郁的研究在 2013 年发生了范式转移,形成维 生素 D 和氧化应激为主的研究方向。 研究前沿为肠菌、5-羟色胺、生化标志物和系统分析,文献地区分布不均,数量上美国遥 遥领先,但高产和影响力较大的作者和文献却来自澳大利亚,以及欧洲国家。 Meta 分析和系统评价在研究中仍受推崇。

Objective To know the status quo of research on vitamins and depression. Method The precise search was conducted in the Web of Science Database and the target literature assemblies of researches on "vitamins" and "depression" were identified. Use the database online analysis tool and NoteExpress software analysis module to carry out general quantitative analysis and use CiteSpace software to carry out network clustering co-occurrence analysis. A systematic review was carried out against the closely related highquality literature combining the results of the bibliometric analysis. Result The search finally yielded 2817 articles which were mainly published in the journals of nutrition and psychiatry and there was 3 timepoint with relatively significant growth. The literature from the USA and Europe accounted for the vast majority. Nine of the top 20 most-cited articles were from the USA 45% while the most prolific authors and high -frequency citations came from Australia and European countries. Keywords such as vitamin D oxidative stress vitamin B12 folic acid vitamin E vitamin A and meta-analysis have received much attention the research frontier includes biomarkers gut microbiota serotonin systematic review etc. Most - cited citations 7 / 20 frontier citations 9 / 14 highest intensity citations 13 / 20 and longest duration citations 18 / 22 are studies on vitamin D and mental health depression-like . The keyword time-zone shows a wave of high-frequency words emerging around 2012 including " stress" "inflammation" " serum 25 hydroxyvitamin D " " vitamin D supplementation " and "C-reactive protein". The citation time-zone shows three-wave gatherings emerging with the last one being denser while the citation clustering timeline shows a distinct temporal trend for different clusters. Conclusion Research on vitamins and depression underwent a paradigm shift in 2013 with vitamin D and oxidative stress dominating the field gut microbiota serotonin biomarker and systematic review being research frontiers. Research is unevenly distributed regionally with the USA leading the way however the most prolific and influential authors and literature are from Australia and Europe countries. Meta-analysis and systematic review are still trusted by researchers.